New Jersey Center for Engineered Particulates

2024

Facilitating direct compaction tableting of fine cohesive APIs using dry coated fine excipients: Effect of the excipient size and amount of coated silica

Lin, Z., Cabello, B., Kossor, C. & Davé, R., Jul 20 2024, In: International Journal of Pharmaceutics. 660, 124359.

Research output: Contribution to journal › Article › peer-review

Impact of dry coating lactose as a brittle excipient on multi-component blend processability

Lin, Z., Cabello, B. & Davé, R. N., Mar 25 2024, In: International Journal of Pharmaceutics. 653, 123921.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

On predicting the performance of different silicas on key property enhancements of fine APIs, blends, and tablets

Kim, S. S., Seetahal, A., Kossor, C. & Davé, R. N., Jan 2 2024, In: Powder Technology. 432, 119104.

Research output: Contribution to journal › Article › peer-review

2023

A comparative analysis of steel and alumina balls in fine milling of cement clinker via PBM and DEM

Muanpaopong, N., Davé, R. & Bilgili, E., May 1 2023, In: Powder Technology. 421, 118454.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Application of TUSSIM with a variable Tromp curve for predicting optimal operation of multi-compartment mills with various ball size distributions

Muanpaopong, N., Davé, R. & Bilgili, E., Oct 2023, In: Advanced Powder Technology. 34, 10, 104171.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: The effect of mixing time and excipient size

Kim, S. S., Castillo, C., Cheikhali, M., Darweesh, H., Kossor, C. & Davé, R. N., Mar 25 2023, In: International Journal of Pharmaceutics. 635, 122722.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Impact of Silica Dry Coprocessing with API and Blend Mixing Time on Blend Flowability and Drug Content Uniformity

Kim, S. S., Seetahal, A., Amores, N., Kossor, C. & Davé, R. N., Aug 2023, In: Journal of Pharmaceutical Sciences. 112, 8, p. 2124-2136 13 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Modeling of closed-circuit ball milling of cement clinker via a PBM with a variable Tromp curve for classification

Muanpaopong, N., Davé, R. & Bilgili, E., Sep 1 2023, In: Powder Technology. 427, 118737.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Preparation of Free-Flowing Spray-Dried Amorphous Composites Using Neusilin^®

Lin, Z., Zheng, K., Azad, M. A. & Davé, R. N., Jan 2023, In: AAPS PharmSciTech. 24, 1, 51.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Selection of Silica Type and Amount for Flowability Enhancements via Dry Coating: Contact Mechanics Based Predictive Approach

Kunnath, K. T., Tripathi, S., Kim, S. S., Chen, L., Zheng, K. & Davé, R. N., Dec 2023, In: Pharmaceutical Research. 40, 12, p. 2917-2933 17 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2022

A cell-based PBM for continuous open-circuit dry milling: Impact of axial mixing, nonlinear breakage, and screen size

Muanpaopong, N., Davé, R. & Bilgili, E., Feb 2022, In: Powder Technology. 399, 117099.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Decoding Fine API Agglomeration as a Key Indicator of Powder Flowability and Dissolution: Impact of Particle Engineering

Kim, S., Cheikhali, M. & Davé, R. N., Dec 2022, In: Pharmaceutical Research. 39, 12, p. 3079-3098 20 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Discrete element method simulation of binary blend mixing of cohesive particles in a high-intensity vibration system

Zheng, K., Kunnath, K. & Davé, R. N., Apr 2022, In: AIChE Journal. 68, 4, e17603.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Dose Titration of Solid Dosage Forms via FDM 3D-Printed Mini-Tablets

Gorkem Buyukgoz, G., Kossor, C. G., Ji, S., Guvendiren, M. & Davé, R. N., Nov 2022, In: Pharmaceutics. 14, 11, 2305.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Hydrogel-Embedded Poly(Lactic-co-Glycolic Acid) Microspheres for the Delivery of hMSC-Derived Exosomes to Promote Bioactive Annulus Fibrosus Repair

DiStefano, T. J., Vaso, K., Panebianco, C. J., Danias, G., Chionuma, H. N., Kunnath, K., Karoulias, S. Z., Wang, M., Xu, P., Davé, R. N., Sahoo, S., Weiser, J. R. & Iatridis, J. C., Jul 2022, In: Cartilage. 13, 3

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Impact of ball size distribution, compartment configuration, and classifying liner on cement particle size in a continuous ball mill

Muanpaopong, N., Davé, R. & Bilgili, E., Nov 2022, In: Minerals Engineering. 189, 107912.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Reduced Fine API Agglomeration After Dry Coating for Enhanced Blend Uniformity and Processability of Low Drug Loaded Blends

Kim, S. S., Castillo, C., Sayedahmed, M. & Davé, R. N., Dec 2022, In: Pharmaceutical Research. 39, 12, p. 3155-3174 20 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2021

Assessing predictability of packing porosity and bulk density enhancements after dry coating of pharmaceutical powders

Kunnath, K., Chen, L., Zheng, K. & Davé, R. N., Jan 2 2021, In: Powder Technology. 377, p. 709-722 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Enhanced supersaturation via fusion-assisted amorphization during fdm 3d printing of crystalline poorly soluble drug loaded filaments

Buyukgoz, G. G., Kossor, C. G. & Davé, R. N., Nov 2021, In: Pharmaceutics. 13, 11, 1857.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Impact of altered hydrophobicity and reduced agglomeration on dissolution of micronized poorly water-soluble drug powders after dry coating

Kim, S., Bilgili, E. & Davé, R. N., Sep 5 2021, In: International Journal of Pharmaceutics. 606, 120853.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Impact of matrix surface area on griseofulvin release from extrudates prepared via nanoextrusion

Li, M., Furey, C., Skros, J., Xu, O., Rahman, M., Azad, M., Dave, R. & Bilgili, E., Jul 2021, In: Pharmaceutics. 13, 7, 1036.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Impact of mixing on content uniformity of thin polymer films containing drug micro-doses

Buyukgoz, G. G., Castro, J. N., Atalla, A. E., Pentangelo, J. G., Tripathi, S. & Davé, R. N., Jun 2021, In: Pharmaceutics. 13, 6, 812.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Impact of solvents during wet stirred media milling of cross-linked biopolymer suspensions

Azad, M., Guner, G., Afolabi, A., Davé, R. & Bilgili, E., Dec 2021, In: Advanced Powder Technology. 32, 12, p. 4562-4575 14 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2020

Efavirenz nanomicelles loaded vaginal film (EZ film) for preexposure prophylaxis (PrEP) of HIV

Patki, M., Vartak, R., Jablonski, J., Mediouni, S., Gandhi, T., Fu, Y., Cetindag, E., Dave, R., Valente, S. T. & Patel, K., Oct 2020, In: Colloids and Surfaces B: Biointerfaces. 194, 111174.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Effect of solvents and cellulosic polymers on quality attributes of films loaded with a poorly water-soluble drug

Cetindag, E., Pentangelo, J., Arrieta Cespedes, T. & Davé, R. N., Dec 15 2020, In: Carbohydrate Polymers. 250, 117012.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Exploring tablet design options for tailoring drug release and dose via fused deposition modeling (FDM) 3D printing

Gorkem Buyukgoz, G., Soffer, D., Defendre, J., Pizzano, G. M. & Davé, R. N., Dec 15 2020, In: International Journal of Pharmaceutics. 591, 119987.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Fine grade engineered microcrystalline cellulose excipients for direct compaction: Assessing suitability of different dry coating processes

Chen, L., He, Z., Kunnath, K., Zheng, K., Kim, S. & Davé, R. N., Aug 1 2020, In: European Journal of Pharmaceutical Sciences. 151, 105408.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Influence of guest and host particle sizes on dry coating effectiveness: When not to use high mixing intensity

Zheng, K., Kunnath, K., Ling, Z., Chen, L. & Davé, R. N., Apr 15 2020, In: Powder Technology. 366, p. 150-163 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2019

A predictive transport model for convective drying of polymer strip films loaded with a BCS Class II drug

Naseri, A. T., Cetindag, E., Bilgili, E. & Davé, R. N., Apr 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 164-174 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Convective Drying Kinetics of Polymer Strip Films Loaded with a BCS Class II Drug

Naseri, A. T., Cetindag, E., Forte, J., Bilgili, E. & Davé, R. N., Feb 1 2019, In: AAPS PharmSciTech. 20, 2, 40.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Effect of Particle Size and Polymer Loading on Dissolution Behavior of Amorphous Griseofulvin Powder

Zheng, K., Lin, Z., Capece, M., Kunnath, K., Chen, L. & Davé, R. N., Jan 2019, In: Journal of Pharmaceutical Sciences. 108, 1, p. 234-242 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Fenofibrate nanocrystal composite microparticles for intestine-specific oral drug delivery system

Kevadiya, B. D., Chen, L., Zhang, L., Thomas, M. B. & Davé, R. N., Sep 2019, In: Pharmaceuticals. 12, 3, 109.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Surface engineered excipients: III. Facilitating direct compaction tableting of binary blends containing fine cohesive poorly-compactable APIs

Chen, L., He, Z., Kunnath, K. T., Fan, S., Wei, Y., Ding, X., Zheng, K. & Davé, R. N., Feb 25 2019, In: International Journal of Pharmaceutics. 557, p. 354-365 12 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

2018

A pseudo-coupled DEM–non-linear PBM approach for simulating the evolution of particle size during dry milling

Capece, M., Davé, R. N. & Bilgili, E., Jan 1 2018, In: Powder Technology. 323, p. 374-384 11 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Discrete element method based analysis of mixing and collision dynamics in adhesive mixing process

Deng, X., Zheng, K. & Davé, R. N., Nov 23 2018, In: Chemical Engineering Science. 190, p. 220-231 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Fast release of liquid antisolvent precipitated fenofibrate at high drug loading from biocompatible thin films

Azad, M. A., Sievens-Figueroa, L. & Davé, R. N., Dec 2018, In: Advanced Powder Technology. 29, 12, p. 2907-2919 13 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Impact of dispersants on dissolution of itraconazole from drug-loaded, surfactant-free, spray-dried nanocomposites

Li, M., Suriel, I., Vekaria, J., Proske, J., Orbe, P., Armani, M., Dave, R. N. & Bilgili, E., Nov 2018, In: Powder Technology. 339, p. 281-295 15 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Impact of Superdisintegrants and Film Thickness on Disintegration Time of Strip Films Loaded With Poorly Water-Soluble Drug Microparticles

Zhang, L., Aloia, M., Pielecha-Safira, B., Lin, H., Rajai, P. M., Kunnath, K. & Davé, R. N., Aug 2018, In: Journal of Pharmaceutical Sciences. 107, 8, p. 2107-2118 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Improved properties of fine active pharmaceutical ingredient powder blends and tablets at high drug loading via dry particle coating

Kunnath, K., Huang, Z., Chen, L., Zheng, K. & Davé, R., May 30 2018, In: International Journal of Pharmaceutics. 543, 1-2, p. 288-299 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

Incorporation of surface-modified dry micronized poorly water-soluble drug powders into polymer strip films

Zhang, L., Li, Y., Abed, M. & Davé, R. N., Jan 15 2018, In: International Journal of Pharmaceutics. 535, 1-2, p. 462-472 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Quiescent and Agitated Redispersion as a Tool for Evaluating Dispersant Effectiveness in Dissolution Enhancement of Drug-Laden Nanocomposites

Bhakay, A., Davé, R. N. & Bilgili, E., Jan 1 2018, In: AAPS PharmSciTech. 19, 1, p. 436-447 12 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Special issue of the 8th World Congress on Particle Technology (WCPT8): Applications of particle technology for pharmaceuticals

Davé, R. N., Bilgili, E. & Wang, C. H., Dec 2018, In: Advanced Powder Technology. 29, 12, p. 2905-2906 2 p.

Research output: Contribution to journal › Article › peer-review

Stable and Fast-Dissolving Amorphous Drug Composites Preparation via Impregnation of Neusilin^® UFL2

Azad, M., Moreno, J. & Davé, R., Jan 2018, In: Journal of Pharmaceutical Sciences. 107, 1, p. 170-182 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Surface engineered excipients: I. improved functional properties of fine grade microcrystalline cellulose

Chen, L., Ding, X., He, Z., Huang, Z., Kunnath, K. T., Zheng, K. & Davé, R. N., Jan 30 2018, In: International Journal of Pharmaceutics. 536, 1, p. 127-137 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Surface engineered excipients: II. Simultaneous milling and dry coating for preparation of fine-grade microcrystalline cellulose with enhanced properties

Chen, L., Ding, X., He, Z., Fan, S., Kunnath, K. T., Zheng, K. & Davé, R. N., Jul 30 2018, In: International Journal of Pharmaceutics. 546, 1-2, p. 125-136 12 p.

Research output: Contribution to journal › Article › peer-review