Non-protein ubiquitination in disease and inflammation

Regulation of different signals and processes is key to cellular health. A major way cells achieve this is attaching the small protein ‘ubiquitin’ to specific targets. This acts as a code, read by other proteins and results in changes to cell function. Recently, new players in this code have been identified but we have limited ways to ‘see’ them in cells. Our research will discover and understand the role of these new players in ubiquitin signalling during infection, cell death and inflammation.