DESCRIPTION (provided by applicant): Following spinal cord damage from trauma or disease, skeletal muscles distal to the point of damage become paralyzed due to disrupted neural conduction. In high-level spinal cord injury/damage, there is a great need for a method that can substitute for the voluntary control in order to regain self-mobility, environmental control, and computer access. Each year about 15,000 spinal cord injuries occur in the US. Majority of these cases survive and depend on others for their basic needs. The average life expectancy of this population is 40 years. Current Solution: 'Brain-Computer Interfaces' have been developed to extract the volitional control information from various brain cortices. Activity of single neurons is recorded with micro electrode/wire arrays implanted and interpreted with advanced signal processing algorithms. Shortcomings: There remain two major problems after many years of research that are inherent to single spike recording method from the cerebral cortex. First, the population of neurons recorded from changes day to day, thus requiring a training session for the signal processing algorithm before each use. The number of good electrodes that record neural activity in an array (yield) is low and the single spike signals are lost completely after sometime due to glial cell growth around the electrode. Second, the information provided by each neuron is very noisy. A very large number of neurons need to be sampled to achieve stable and finely tunable command signals. This requires many electrode arrays implanted in multiple brain areas. Our Proposal: The alternative method proposed here is to extract the volitional motor signals from the proximal spinal cord that is still intact above the site of injury and use the population activity of the axons in the motor tracts rather than single spikes. The distal portions of the severed motor axons go through Wallerian degeneration. However, the proximal part of the axon continues to function years after injury since its connection to the cell body in the brain remains intact. Spinal cord approach has at least two important advantages. First, the recorded neural signals will be strongly coupled to the motor function due to closeness of the spinal cord to the motor apparatus in the signal path. Second, the neural recordings will be much more stable because the method relies on the population activity rather than single spikes.
|Effective start/end date||9/15/11 → 8/31/17|
- National Institutes of Health
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