Testing an implementable strategy to modulate immune function and reduce inflammation to prevent asthma and preserve lung function: 6-year follow-up of the existing VITALITY RCT.

We will test if a simple and well tolerated intervention, daily vitamin D drops in the first year of life, can prevent asthma and lung function deficits. This trial may change global infant nutrition recommendations and reduce the lifelong effects of respiratory disease. This is an age 6 years follow-up study of our large NHMRC funded trial, VITALITY, which recruited 2739 children, and is testing if this intervention (vitamin D) can prevent food allergy and eczema at age 1.