3-D volume reconstruction of skin lesions for melanin and blood volume estimation and lesion severity analysis

Brian D'Alessandro, Atam P. Dhawan

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Subsurface information about skin lesions, such as the blood volume beneath the lesion, is important for the analysis of lesion severity towards early detection of skin cancer such as malignant melanoma. Depth information can be obtained from diffuse reflectance based multispectral transillumination images of the skin. An inverse volume reconstruction method is presented which uses a genetic algorithm optimization procedure with a novel population initialization routine and nudge operator based on the multispectral images to reconstruct the melanin and blood layer volume components. Forward model evaluation for fitness calculation is performed using a parallel processing voxel-based Monte Carlo simulation of light in skin. Reconstruction results for simulated lesions show excellent volume accuracy. Preliminary validation is also done using a set of 14 clinical lesions, categorized into lesion severity by an expert dermatologist. Using two features, the average blood layer thickness and the ratio of blood volume to total lesion volume, the lesions can be classified into mild and moderate/severe classes with 100% accuracy. The method therefore has excellent potential for detection and analysis of pre-malignant lesions.

Original languageEnglish (US)
Article number6243210
Pages (from-to)2083-2092
Number of pages10
JournalIEEE Transactions on Medical Imaging
Issue number11
StatePublished - 2012

All Science Journal Classification (ASJC) codes

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


  • Dermoscopy
  • hemoglobin
  • melanoma
  • multispectral imaging
  • skin lesions
  • transillumination
  • volume reconstruction


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