TY - GEN
T1 - 3D Printing of Pharmaceuticals and Transdermal Drug Delivery––An Overview
AU - Bird, David
AU - Eker, Emel
AU - Ravindra, Nuggehalli M.
N1 - Publisher Copyright:
© 2019, The Minerals, Metals & Materials Society.
PY - 2019
Y1 - 2019
N2 - Three-dimensional printing is a novel technique offering the ability to print transdermal drug delivery systems on demand. Such printing techniques have already been used in the fields of dentistry, orthopedics and pharmaceuticals; highlighting the latter, printing medical devices and various active pharmaceutical ingredient formulations, which possess various geometries with controlled release characteristics, have also been utilized. An overview of these pharmaceuticals is presented in this study, with an emphasis on transdermal patches that can be 3D printed. Several printing technologies and material systems are discussed, which are customizable and generate complex geometries with inherent precision that satisfy the transdermal system and enhance bioavailability. Case studies, advantages and limitations of the technology are discussed. Industry forecasts based on this technology is predicted to reach over USD 8 Billion by 2025, but the pharmaceutical industry is conservative and utilizes cost-effective methods for large-scale production. 3D Printing could revolutionize current ‘one size fits all’ manufacturing and would be utilized throughout the drug development timeline.
AB - Three-dimensional printing is a novel technique offering the ability to print transdermal drug delivery systems on demand. Such printing techniques have already been used in the fields of dentistry, orthopedics and pharmaceuticals; highlighting the latter, printing medical devices and various active pharmaceutical ingredient formulations, which possess various geometries with controlled release characteristics, have also been utilized. An overview of these pharmaceuticals is presented in this study, with an emphasis on transdermal patches that can be 3D printed. Several printing technologies and material systems are discussed, which are customizable and generate complex geometries with inherent precision that satisfy the transdermal system and enhance bioavailability. Case studies, advantages and limitations of the technology are discussed. Industry forecasts based on this technology is predicted to reach over USD 8 Billion by 2025, but the pharmaceutical industry is conservative and utilizes cost-effective methods for large-scale production. 3D Printing could revolutionize current ‘one size fits all’ manufacturing and would be utilized throughout the drug development timeline.
KW - Pharmaceuticals
KW - Three-dimensional printing
KW - Transdermal drug delivery systems
UR - http://www.scopus.com/inward/record.url?scp=85064878716&partnerID=8YFLogxK
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U2 - 10.1007/978-3-030-05861-6_147
DO - 10.1007/978-3-030-05861-6_147
M3 - Conference contribution
AN - SCOPUS:85064878716
SN - 9783030058609
T3 - Minerals, Metals and Materials Series
SP - 1563
EP - 1573
BT - TMS 2019 148th Annual Meeting and Exhibition Supplemental Proceedings
PB - Springer International Publishing
T2 - 148th Annual Meeting and Exhibition of The Minerals, Metals and Materials Society, TMS 2019
Y2 - 10 March 2019 through 14 March 2019
ER -