A BODIPY-Based Water-Soluble Fluorescent Probe for Mitochondria Targeting

Binglin Sui, Simon Tang, Adam W. Woodward, Bosung Kim, Kevin D. Belfield

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A water-soluble fluorescent mitochondrial targeting probe is reported. The probe bears a BODIPY-based fluorophore, two triphenylphosphonium (TPP) groups as mitochondrial targeting moieties, and two PEG groups to increase water solubility and enhance biocompatibility. As a mitochondria-selective fluorescent probe, the new BODIPY derivative exhibited many desirable properties, such as water solubility, high fluorescence quantum yield, solvent independent photophysical properties, pH insensitivity, good photostability, low cytotoxicity, and excellent mitochondrial targeting ability. Fluorescence microscopy colocalization experiments demonstrated the ability of this new probe to target mitochondria within living cells for bioimaging.

Original languageEnglish (US)
Pages (from-to)2851-2857
Number of pages7
JournalEuropean Journal of Organic Chemistry
Volume2016
Issue number16
DOIs
StatePublished - Jun 2016

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Keywords

  • Cytotoxicity
  • Fluorescent probes
  • Imaging agents
  • Mitochondria targeting
  • Photophysics

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