TY - JOUR
T1 - A BODIPY-Based Water-Soluble Fluorescent Probe for Mitochondria Targeting
AU - Sui, Binglin
AU - Tang, Simon
AU - Woodward, Adam W.
AU - Kim, Bosung
AU - Belfield, Kevin D.
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/6
Y1 - 2016/6
N2 - A water-soluble fluorescent mitochondrial targeting probe is reported. The probe bears a BODIPY-based fluorophore, two triphenylphosphonium (TPP) groups as mitochondrial targeting moieties, and two PEG groups to increase water solubility and enhance biocompatibility. As a mitochondria-selective fluorescent probe, the new BODIPY derivative exhibited many desirable properties, such as water solubility, high fluorescence quantum yield, solvent independent photophysical properties, pH insensitivity, good photostability, low cytotoxicity, and excellent mitochondrial targeting ability. Fluorescence microscopy colocalization experiments demonstrated the ability of this new probe to target mitochondria within living cells for bioimaging.
AB - A water-soluble fluorescent mitochondrial targeting probe is reported. The probe bears a BODIPY-based fluorophore, two triphenylphosphonium (TPP) groups as mitochondrial targeting moieties, and two PEG groups to increase water solubility and enhance biocompatibility. As a mitochondria-selective fluorescent probe, the new BODIPY derivative exhibited many desirable properties, such as water solubility, high fluorescence quantum yield, solvent independent photophysical properties, pH insensitivity, good photostability, low cytotoxicity, and excellent mitochondrial targeting ability. Fluorescence microscopy colocalization experiments demonstrated the ability of this new probe to target mitochondria within living cells for bioimaging.
KW - Cytotoxicity
KW - Fluorescent probes
KW - Imaging agents
KW - Mitochondria targeting
KW - Photophysics
UR - http://www.scopus.com/inward/record.url?scp=84971261006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971261006&partnerID=8YFLogxK
U2 - 10.1002/ejoc.201600238
DO - 10.1002/ejoc.201600238
M3 - Article
AN - SCOPUS:84971261006
SN - 1434-193X
VL - 2016
SP - 2851
EP - 2857
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 16
ER -