A combined nanocolloid-nanochannel platform for sensitive biomolecular detection

Gilad Yossifon, Sagnik Basuray, Peter Musenheim, Thomas Hagen, Hsueh Chia Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we discuss the fundamental mechanisms behind which nanocolloids/biomolecules trapped at the entrance can produce the largest change in the conductance/impedance signature. Nanocolloids trapped at the depleted side of a fluidic nanoslot entrance are shown to sensitively regulate DC ion transport through the nanoslot, such that a second limiting-overlimiting transition occurs in its nonlinear current-voltage characteristics. The same nanoslot is shown to be able to directly quantify DNA concentration with nano-molar sensitivity, however, lacking of any specificity. Hence, suggesting a combination of these two platforms (nanocolloids functionalized with specific molecular probes and a nanochannel) for extremely specific, sensitive and non-optical biomolecular detection.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages470-472
Number of pages3
StatePublished - 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Keywords

  • Biomolecular detection
  • Concentration-polarization
  • Nanochannel
  • Nanocolloid

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