TY - JOUR
T1 - A concise treatise on model-based enhancements of cohesive powder properties via dry particle coating
AU - Davé, Rajesh
AU - Kim, Sangah
AU - Kunnath, Kuriakose
AU - Tripathi, Siddharth
N1 - Publisher Copyright:
© 2022 The Society of Powder Technology Japan
PY - 2022/11
Y1 - 2022/11
N2 - This paper presents a review of our key advances in model-guided dry coating-based enhancements of poor flow and packing of fine cohesive powders. The existing van der Waals force-based particle-contact models are reviewed to elucidate the main mechanism of flow enhancement through silica dry coating. Our multi-asperity model explains the effect of the amount of silica, insufficient flowability enhancements through conventional blending, and the predominant effect of particle surface roughness on cohesion reduction. Models are presented for the determination of the amount and type of guest particles, and estimation of the granular Bond number, used for cohesion nondimensionalization, based on particle size, particle density, asperity size, surface area coverage, and dispersive surface energy. Selection of the processing conditions for LabRAM, a benchmarking device, is presented followed by key examples of enhancements of flow, packing, agglomeration, and dissolution through the dry coating. Powder agglomeration is shown as a screening indicator of powder flowability. The mixing synergy is identified as a cause for enhanced blend flowability with a minor dry coated constituent at silica < 0.01%. The analysis and outcomes presented in this paper are intended to demonstrate the importance of dry coating as an essential tool for industry practitioners.
AB - This paper presents a review of our key advances in model-guided dry coating-based enhancements of poor flow and packing of fine cohesive powders. The existing van der Waals force-based particle-contact models are reviewed to elucidate the main mechanism of flow enhancement through silica dry coating. Our multi-asperity model explains the effect of the amount of silica, insufficient flowability enhancements through conventional blending, and the predominant effect of particle surface roughness on cohesion reduction. Models are presented for the determination of the amount and type of guest particles, and estimation of the granular Bond number, used for cohesion nondimensionalization, based on particle size, particle density, asperity size, surface area coverage, and dispersive surface energy. Selection of the processing conditions for LabRAM, a benchmarking device, is presented followed by key examples of enhancements of flow, packing, agglomeration, and dissolution through the dry coating. Powder agglomeration is shown as a screening indicator of powder flowability. The mixing synergy is identified as a cause for enhanced blend flowability with a minor dry coated constituent at silica < 0.01%. The analysis and outcomes presented in this paper are intended to demonstrate the importance of dry coating as an essential tool for industry practitioners.
KW - Cohesive powder property enhancements
KW - Dry coating
KW - Particle contact models
KW - Pharmaceutical blends
KW - van der Waals forces
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U2 - 10.1016/j.apt.2022.103836
DO - 10.1016/j.apt.2022.103836
M3 - Review article
AN - SCOPUS:85140135857
SN - 0921-8831
VL - 33
JO - Advanced Powder Technology
JF - Advanced Powder Technology
IS - 11
M1 - 103836
ER -