A Highly Selective Fluorescence Turn-On Sensor for Extracellular Calcium Ion Detection

Binglin Sui; Xinglei Liu; Mengyuan Wang; Kevin D. Belfield

doi:10.1002/chem.201602162

A Highly Selective Fluorescence Turn-On Sensor for Extracellular Calcium Ion Detection

Binglin Sui, Xinglei Liu, Mengyuan Wang, Kevin D. Belfield

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A highly water-soluble, fluorescence turn-on sensor for Ca²⁺is reported. The sensor affords high selectivity in sensing Ca²⁺over other biologically important metal cations. The dissociation constant of the sensor in binding Ca²⁺is 0.92 mm. Fluorescence microscopy experiments demonstrate that the sensor is cell-impermeable and capable of detecting extracellular Ca²⁺.

Original language	English (US)
Pages (from-to)	10351-10354
Number of pages	4
Journal	Chemistry - A European Journal
Volume	22
Issue number	30
DOIs	https://doi.org/10.1002/chem.201602162
State	Published - Jul 18 2016

All Science Journal Classification (ASJC) codes

Catalysis
Organic Chemistry

Keywords

calcium
cell imaging
extracellular calcium detection
fluorescence microscopy
fluorescence sensors

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10.1002/chem.201602162

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abstract = "A highly water-soluble, fluorescence turn-on sensor for Ca2+is reported. The sensor affords high selectivity in sensing Ca2+over other biologically important metal cations. The dissociation constant of the sensor in binding Ca2+is 0.92 mm. Fluorescence microscopy experiments demonstrate that the sensor is cell-impermeable and capable of detecting extracellular Ca2+.",

keywords = "calcium, cell imaging, extracellular calcium detection, fluorescence microscopy, fluorescence sensors",

author = "Binglin Sui and Xinglei Liu and Mengyuan Wang and Belfield, {Kevin D.}",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AU - Sui, Binglin

AU - Liu, Xinglei

AU - Wang, Mengyuan

AU - Belfield, Kevin D.

PY - 2016/7/18

Y1 - 2016/7/18

N2 - A highly water-soluble, fluorescence turn-on sensor for Ca2+is reported. The sensor affords high selectivity in sensing Ca2+over other biologically important metal cations. The dissociation constant of the sensor in binding Ca2+is 0.92 mm. Fluorescence microscopy experiments demonstrate that the sensor is cell-impermeable and capable of detecting extracellular Ca2+.

AB - A highly water-soluble, fluorescence turn-on sensor for Ca2+is reported. The sensor affords high selectivity in sensing Ca2+over other biologically important metal cations. The dissociation constant of the sensor in binding Ca2+is 0.92 mm. Fluorescence microscopy experiments demonstrate that the sensor is cell-impermeable and capable of detecting extracellular Ca2+.

KW - calcium

KW - cell imaging

KW - extracellular calcium detection

KW - fluorescence microscopy

KW - fluorescence sensors

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JF - Chemistry - A European Journal

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ER -

A Highly Selective Fluorescence Turn-On Sensor for Extracellular Calcium Ion Detection

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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