TY - JOUR
T1 - A mathematical model of an aqueous-organic partition-based controlled release system using microporous membranes
AU - Farrell, Stephanie
AU - Sirkar, Kamalesh K.
N1 - Funding Information:
This project was supported by the Membrane Separations and Biotechnology Program at the New Jersey Institute of Technology. The authors gratefully acknowledge the comments and suggestions of Professor Norman Loney at NJIT. The Celgard® flat membranes were graciously donated by Hoechst Celanese Separations Products Division, Charlotte, NC. Enka America, Inc., Technical Membranes Group, Ashville, NC kindly donated the Nylon hollow fibers used in this work.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1999/9/20
Y1 - 1999/9/20
N2 - A mathematical model with an exact solution is presented for the membrane-controlled release of small molecules such as nicotine, caffeine, and benzoic acid initially present in solution in the reservoir of the device. Both hollow fiber and flat membrane device geometries are considered. The reservoir is bounded by a microporous membrane, the pores of which are filled with a pore liquid immiscible with the reservoir phase liquid. At the interface between the reservoir and the pore, the solute partitions between the reservoir and the pore liquid phases, before diffusing outward through the membrane pore. The model results compare well with experimental data. Parametric studies reveal the interaction between system parameters and the controlled release behavior. A high partition coefficient of the solute between the reservoir and pore phases is found to effect pseudo-zero order release for an extended time. Similarly, when the ratio of time constants for transport of the solute through the reservoir and membrane regions is small, a constant release rate is achieved for an extended time. Copyright (C) 1999 Elsevier Science B.V.
AB - A mathematical model with an exact solution is presented for the membrane-controlled release of small molecules such as nicotine, caffeine, and benzoic acid initially present in solution in the reservoir of the device. Both hollow fiber and flat membrane device geometries are considered. The reservoir is bounded by a microporous membrane, the pores of which are filled with a pore liquid immiscible with the reservoir phase liquid. At the interface between the reservoir and the pore, the solute partitions between the reservoir and the pore liquid phases, before diffusing outward through the membrane pore. The model results compare well with experimental data. Parametric studies reveal the interaction between system parameters and the controlled release behavior. A high partition coefficient of the solute between the reservoir and pore phases is found to effect pseudo-zero order release for an extended time. Similarly, when the ratio of time constants for transport of the solute through the reservoir and membrane regions is small, a constant release rate is achieved for an extended time. Copyright (C) 1999 Elsevier Science B.V.
KW - Aqueous-organic partitioning
KW - Diffusional release kinetics
KW - Mathematical model
KW - Membrane-controlled release
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U2 - 10.1016/S0168-3659(99)00154-6
DO - 10.1016/S0168-3659(99)00154-6
M3 - Article
C2 - 10477807
AN - SCOPUS:0032877830
SN - 0168-3659
VL - 61
SP - 345
EP - 360
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 3
ER -