@article{d6f51ebf428c4879b0a560bd93e554b4,
title = "A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes",
abstract = "Neuroimaging studies have identified brain structural and functional alterations of type 2 diabetes mellitus (T2DM) patients; however, there is no systematic information on the relations between abnormalities in these two domains. We conducted a multimodal meta-analysis of voxel-based morphometry and regional resting-state functional MRI studies in T2DM, including fifteen structural datasets (693 patients and 684 controls) and sixteen functional datasets (378 patients and 358 controls). We found, in patients with T2DM compared to controls, conjoint decreased regional gray matter volume (GMV) and altered intrinsic activity mainly in the default mode network including bilateral superior temporal gyrus/Rolandic operculum, left middle and inferior temporal gyrus, and left supramarginal gyrus; decreased GMV alone in the limbic system; and functional abnormalities alone in the cerebellum, insula, and visual cortex. This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in T2DM patients, which may help provide new insight into the neuropathology of T2DM.",
keywords = "Gray matter volume, Meta-analysis, Multimodal, Resting-state function, Type 2 diabetes mellitus",
author = "Li Yao and Chengmin Yang and Wenjing Zhang and Siyi Li and Qian Li and Lizhou Chen and Su Lui and Kemp, {Graham J.} and Biswal, {Bharat B.} and Shah, {Nadim J.} and Fei Li and Qiyong Gong",
note = "Funding Information: This work was supported by the National Natural Science Foundation of China (Nos. 81801683 , 82027808 , and 81621003 ), 1.3.5 Project for Disciplines of Excellence (No. ZYYC08001 ) and Dedicated Fund for Resident Research ( YB0000005 ) of West China Hospital of Sichuan University, Science and Technology Project of the Health Planning Committee (Nos. 19PJ078 and 19PJ249 ) and Sichuan Science and Technology Program (No. 2021YFS0077 ) of Sichuan Province. Dr. Lui acknowledges the support from Humboldt Foundation Friedrich Wilhelm Bessel Research Award. The authors would like to acknowledge the support of the Med + X Center for Manufacturing, West China Hospital of Sichuan University. Funding Information: This work was supported by the National Natural Science Foundation of China (Nos. 81801683, 82027808, and 81621003), 1.3.5 Project for Disciplines of Excellence (No. ZYYC08001) and Dedicated Fund for Resident Research (YB0000005) of West China Hospital of Sichuan University, Science and Technology Project of the Health Planning Committee (Nos. 19PJ078 and 19PJ249) and Sichuan Science and Technology Program (No. 2021YFS0077) of Sichuan Province. Dr. Lui acknowledges the support from Humboldt Foundation Friedrich Wilhelm Bessel Research Award. The authors would like to acknowledge the support of the Med + X Center for Manufacturing, West China Hospital of Sichuan University. Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = jul,
doi = "10.1016/j.yfrne.2021.100915",
language = "English (US)",
volume = "62",
journal = "Frontiers in Neuroendocrinology",
issn = "0091-3022",
publisher = "Academic Press Inc.",
}