A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes

Li Yao; Chengmin Yang; Wenjing Zhang; Siyi Li; Qian Li; Lizhou Chen; Su Lui; Graham J. Kemp; Bharat B. Biswal; Nadim J. Shah; Fei Li; Qiyong Gong

doi:10.1016/j.yfrne.2021.100915

A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes

Li Yao, Chengmin Yang, Wenjing Zhang, Siyi Li, Qian Li, Lizhou Chen, Su Lui, Graham J. Kemp, Bharat B. Biswal, Nadim J. Shah, Fei Li, Qiyong Gong

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Neuroimaging studies have identified brain structural and functional alterations of type 2 diabetes mellitus (T2DM) patients; however, there is no systematic information on the relations between abnormalities in these two domains. We conducted a multimodal meta-analysis of voxel-based morphometry and regional resting-state functional MRI studies in T2DM, including fifteen structural datasets (693 patients and 684 controls) and sixteen functional datasets (378 patients and 358 controls). We found, in patients with T2DM compared to controls, conjoint decreased regional gray matter volume (GMV) and altered intrinsic activity mainly in the default mode network including bilateral superior temporal gyrus/Rolandic operculum, left middle and inferior temporal gyrus, and left supramarginal gyrus; decreased GMV alone in the limbic system; and functional abnormalities alone in the cerebellum, insula, and visual cortex. This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in T2DM patients, which may help provide new insight into the neuropathology of T2DM.

Original language	English (US)
Article number	100915
Journal	Frontiers in Neuroendocrinology
Volume	62
DOIs	https://doi.org/10.1016/j.yfrne.2021.100915
State	Published - Jul 2021

All Science Journal Classification (ASJC) codes

Endocrine and Autonomic Systems

Keywords

Gray matter volume
Meta-analysis
Multimodal
Resting-state function
Type 2 diabetes mellitus

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10.1016/j.yfrne.2021.100915

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title = "A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes",

abstract = "Neuroimaging studies have identified brain structural and functional alterations of type 2 diabetes mellitus (T2DM) patients; however, there is no systematic information on the relations between abnormalities in these two domains. We conducted a multimodal meta-analysis of voxel-based morphometry and regional resting-state functional MRI studies in T2DM, including fifteen structural datasets (693 patients and 684 controls) and sixteen functional datasets (378 patients and 358 controls). We found, in patients with T2DM compared to controls, conjoint decreased regional gray matter volume (GMV) and altered intrinsic activity mainly in the default mode network including bilateral superior temporal gyrus/Rolandic operculum, left middle and inferior temporal gyrus, and left supramarginal gyrus; decreased GMV alone in the limbic system; and functional abnormalities alone in the cerebellum, insula, and visual cortex. This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in T2DM patients, which may help provide new insight into the neuropathology of T2DM.",

keywords = "Gray matter volume, Meta-analysis, Multimodal, Resting-state function, Type 2 diabetes mellitus",

author = "Li Yao and Chengmin Yang and Wenjing Zhang and Siyi Li and Qian Li and Lizhou Chen and Su Lui and Kemp, {Graham J.} and Biswal, {Bharat B.} and Shah, {Nadim J.} and Fei Li and Qiyong Gong",

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year = "2021",

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doi = "10.1016/j.yfrne.2021.100915",

language = "English (US)",

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AU - Yao, Li

AU - Yang, Chengmin

AU - Zhang, Wenjing

AU - Li, Siyi

AU - Li, Qian

AU - Chen, Lizhou

AU - Lui, Su

AU - Kemp, Graham J.

AU - Biswal, Bharat B.

AU - Shah, Nadim J.

AU - Li, Fei

AU - Gong, Qiyong

PY - 2021/7

Y1 - 2021/7

N2 - Neuroimaging studies have identified brain structural and functional alterations of type 2 diabetes mellitus (T2DM) patients; however, there is no systematic information on the relations between abnormalities in these two domains. We conducted a multimodal meta-analysis of voxel-based morphometry and regional resting-state functional MRI studies in T2DM, including fifteen structural datasets (693 patients and 684 controls) and sixteen functional datasets (378 patients and 358 controls). We found, in patients with T2DM compared to controls, conjoint decreased regional gray matter volume (GMV) and altered intrinsic activity mainly in the default mode network including bilateral superior temporal gyrus/Rolandic operculum, left middle and inferior temporal gyrus, and left supramarginal gyrus; decreased GMV alone in the limbic system; and functional abnormalities alone in the cerebellum, insula, and visual cortex. This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in T2DM patients, which may help provide new insight into the neuropathology of T2DM.

AB - Neuroimaging studies have identified brain structural and functional alterations of type 2 diabetes mellitus (T2DM) patients; however, there is no systematic information on the relations between abnormalities in these two domains. We conducted a multimodal meta-analysis of voxel-based morphometry and regional resting-state functional MRI studies in T2DM, including fifteen structural datasets (693 patients and 684 controls) and sixteen functional datasets (378 patients and 358 controls). We found, in patients with T2DM compared to controls, conjoint decreased regional gray matter volume (GMV) and altered intrinsic activity mainly in the default mode network including bilateral superior temporal gyrus/Rolandic operculum, left middle and inferior temporal gyrus, and left supramarginal gyrus; decreased GMV alone in the limbic system; and functional abnormalities alone in the cerebellum, insula, and visual cortex. This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in T2DM patients, which may help provide new insight into the neuropathology of T2DM.

KW - Gray matter volume

KW - Meta-analysis

KW - Multimodal

KW - Resting-state function

KW - Type 2 diabetes mellitus

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A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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