A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes

Li Yao, Chengmin Yang, Wenjing Zhang, Siyi Li, Qian Li, Lizhou Chen, Su Lui, Graham J. Kemp, Bharat B. Biswal, Nadim J. Shah, Fei Li, Qiyong Gong

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Neuroimaging studies have identified brain structural and functional alterations of type 2 diabetes mellitus (T2DM) patients; however, there is no systematic information on the relations between abnormalities in these two domains. We conducted a multimodal meta-analysis of voxel-based morphometry and regional resting-state functional MRI studies in T2DM, including fifteen structural datasets (693 patients and 684 controls) and sixteen functional datasets (378 patients and 358 controls). We found, in patients with T2DM compared to controls, conjoint decreased regional gray matter volume (GMV) and altered intrinsic activity mainly in the default mode network including bilateral superior temporal gyrus/Rolandic operculum, left middle and inferior temporal gyrus, and left supramarginal gyrus; decreased GMV alone in the limbic system; and functional abnormalities alone in the cerebellum, insula, and visual cortex. This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in T2DM patients, which may help provide new insight into the neuropathology of T2DM.

Original languageEnglish (US)
Article number100915
JournalFrontiers in Neuroendocrinology
StatePublished - Jul 2021

All Science Journal Classification (ASJC) codes

  • Endocrine and Autonomic Systems


  • Gray matter volume
  • Meta-analysis
  • Multimodal
  • Resting-state function
  • Type 2 diabetes mellitus


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