A nanomembrane-based nucleic acid sensing platform for portable diagnostics

Satyajyoti Senapati, Sagnik Basuray, Zdenek Slouka, Li Jing Cheng, Hsueh Chia Chang

Research output: Chapter in Book/Report/Conference proceedingChapter

21 Scopus citations

Abstract

In this perspective article, we introduce a potentially transformative DNA/RNA detection technology that promises to replace DNA microarray and real-time PCR for field applications. It represents a new microfluidic technology that fully exploits the small spatial dimensions of a biochip and some new phenomena unique to the micro-and nanoscales. More specifically, it satisfies all the requisites for portable on-field applications: fast, small, sensitive, selective, robust, label-and reagent-free, economical to produce, and possibly PCR-free. We discuss the mechanisms behind the technology and introduce some preliminary designs, test results, and prototypes.

Original languageEnglish (US)
Title of host publicationMicrofluidics
Subtitle of host publicationTechnologies and Applications
EditorsBingcheng Lin
Pages153-169
Number of pages17
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameTopics in Current Chemistry
Volume304
ISSN (Print)0340-1022

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Keywords

  • Depletion
  • Dielectrophoresis
  • Ion-selective membranes
  • Limiting-current

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