@inproceedings{04d66d64a2bf4bce93d505d83efbbb12,
title = "A new systematic methodology to determine drug's solubility in polymer",
abstract = "The solubility of a drug in a polymeric excipient dictates the process window of hot-melt extrusion (HME) and product stability during storage. In this study, a new systematic methodology has been developed to experimentally measure the solubility of a model drug in a pharmaceutical grade polymer at different temperatures. A {"}phase diagram{"} was constructed and could be explored to design the HME process. Flory-Huggins interaction parameter (χ) was calculated by Tdissolution depression method based on the {"}phase diagram{"} and was used for thermodynamic solubility calculation.",
keywords = "Flory-Huggins, Glass transition, Hot-melt mixing, Poly(ethylene oxide)/PEO, Rheology, Solid dispersion, Solubility",
author = "Min Yang and Gogos, {Costas G.} and Peng Wang",
year = "2011",
language = "English (US)",
isbn = "9781617829604",
series = "Annual Technical Conference - ANTEC, Conference Proceedings",
pages = "1354--1359",
booktitle = "69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011",
note = "69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011 ; Conference date: 01-05-2011 Through 05-05-2011",
}