A new systematic methodology to determine drug's solubility in polymer

Min Yang, Costas G. Gogos, Peng Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The solubility of a drug in a polymeric excipient dictates the process window of hot-melt extrusion (HME) and product stability during storage. In this study, a new systematic methodology has been developed to experimentally measure the solubility of a model drug in a pharmaceutical grade polymer at different temperatures. A "phase diagram" was constructed and could be explored to design the HME process. Flory-Huggins interaction parameter (χ) was calculated by Tdissolution depression method based on the "phase diagram" and was used for thermodynamic solubility calculation.

Original languageEnglish (US)
Title of host publication69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
Pages1354-1359
Number of pages6
StatePublished - Aug 23 2011
Event69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011 - Boston, MA, United States
Duration: May 1 2011May 5 2011

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume2

Other

Other69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
CountryUnited States
CityBoston, MA
Period5/1/115/5/11

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics

Keywords

  • Flory-Huggins
  • Glass transition
  • Hot-melt mixing
  • Poly(ethylene oxide)/PEO
  • Rheology
  • Solid dispersion
  • Solubility

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