A new water-soluble near-neutral ratiometric fluorescent ph indicator

Sheng Yao; Katherine J. Schafer-Hales; Kevin D. Belfield

doi:10.1364/biomed.2008.bsue90

A new water-soluble near-neutral ratiometric fluorescent ph indicator

Sheng Yao, Katherine J. Schafer-Hales, Kevin D. Belfield

Research output: Contribution to conference › Paper › peer-review

Abstract

Donor-π-acceptor fluorene derivative 1 is a near-neutral pH indicator whose pKa of ~7.0 was determined by both absorption and fluorescence methods. 1 satisfies important criteria for a sensitive ratiomeric fluorescent pH indicator with a distinctive isoemissive point, good dispersion in cell cytosol, and low cytotoxicity. Furthermore, its 2PA cross-section of 100 GM in its neutral form suggests its potential in two-photon fluorescence imaging applications.

Original language	English (US)
Pages	BSuE90
DOIs	https://doi.org/10.1364/biomed.2008.bsue90
State	Published - 2008
Externally published	Yes
Event	Biomedical Optics, BIOMED 2008 - St. Petersburg, FL, United States Duration: Mar 16 2008 → Mar 19 2008

Other

Other	Biomedical Optics, BIOMED 2008
Country/Territory	United States
City	St. Petersburg, FL
Period	3/16/08 → 3/19/08

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Biomaterials
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

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10.1364/biomed.2008.bsue90

Cite this

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title = "A new water-soluble near-neutral ratiometric fluorescent ph indicator",

abstract = "Donor-π-acceptor fluorene derivative 1 is a near-neutral pH indicator whose pKa of ~7.0 was determined by both absorption and fluorescence methods. 1 satisfies important criteria for a sensitive ratiomeric fluorescent pH indicator with a distinctive isoemissive point, good dispersion in cell cytosol, and low cytotoxicity. Furthermore, its 2PA cross-section of 100 GM in its neutral form suggests its potential in two-photon fluorescence imaging applications.",

author = "Sheng Yao and Schafer-Hales, {Katherine J.} and Belfield, {Kevin D.}",

year = "2008",

doi = "10.1364/biomed.2008.bsue90",

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AU - Yao, Sheng

AU - Schafer-Hales, Katherine J.

AU - Belfield, Kevin D.

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AB - Donor-π-acceptor fluorene derivative 1 is a near-neutral pH indicator whose pKa of ~7.0 was determined by both absorption and fluorescence methods. 1 satisfies important criteria for a sensitive ratiomeric fluorescent pH indicator with a distinctive isoemissive point, good dispersion in cell cytosol, and low cytotoxicity. Furthermore, its 2PA cross-section of 100 GM in its neutral form suggests its potential in two-photon fluorescence imaging applications.

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U2 - 10.1364/biomed.2008.bsue90

DO - 10.1364/biomed.2008.bsue90

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T2 - Biomedical Optics, BIOMED 2008

Y2 - 16 March 2008 through 19 March 2008

ER -

A new water-soluble near-neutral ratiometric fluorescent ph indicator

Abstract

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All Science Journal Classification (ASJC) codes

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