Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is "nuisance".
All Science Journal Classification (ASJC) codes
- Ecology, Evolution, Behavior and Systematics
- Animal Science and Zoology
- Censored trait
- Interval mapping
- QTL detecting