A novel local learning based approach with application to breast cancer diagnosis

Songhua Xu, Georgia Tourassi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


In this paper, we introduce a new local learning based approach and apply it for the well-studied problem of breast cancer diagnosis using BIRADS-based mammographic features. To learn from our clinical dataset the latent relationship between these features and the breast biopsy result, our method first dynamically partitions the whole sample population into multiple sub-population groups through stochastically searching the sample population clustering space. Each encountered clustering scheme in our online searching process is then used to create a certain sample population partition plan. For every resultant sub-population group identified according to a partition plan, our method then trains a dedicated local learner to capture the underlying data relationship. In our study, we adopt the linear logistic regression model as our local learning method's base learner. Such a choice is made both due to the well-understood linear nature of the problem, which is compellingly revealed by a rich body of prior studies, and the computational efficiency of linear logistic regression-the latter feature allows our local learning method to more effectively perform its search in the sample population clustering space. Using a database of 850 biopsy-proven cases, we compared the performance of our method with a large collection of publicly available state-of-the-art machine learning methods and successfully demonstrated its performance advantage with statistical significance.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2012
Subtitle of host publicationComputer-Aided Diagnosis
StatePublished - 2012
Externally publishedYes
EventMedical Imaging 2012: Computer-Aided Diagnosis - San Diego, CA, United States
Duration: Feb 7 2012Feb 9 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2012: Computer-Aided Diagnosis
Country/TerritoryUnited States
CitySan Diego, CA

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


  • Breast cancer diagnosis prediction
  • Classification
  • Local-learning
  • Mammography


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