A PRC description of how inhibitory feedback promotes oscillation stability

Farzan Nadim, Shunbing Zhao, Amitabha Bose

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Using methods of geometric dynamical systems modeling, we demonstrate the mechanism through which inhibitory feedback synapses to oscillatory neurons stabilize the oscillation, resulting in a flattened phase-resetting curve. In particular, we use the concept of a synaptic phase-resetting curve to demonstrate that periodic inhibitory feedback to an oscillatory neuron locks at a stable phase where it has no impact on cycle period and yet it acts to counter the effects of extrinsic perturbations. These results are supported by data from the stable bursting oscillations in the crustacean pyloric central pattern generator.

Original languageEnglish (US)
Title of host publicationPhase Response Curves in Neuroscience
Subtitle of host publicationTheory, Experiment, and Analysis
PublisherSpringer New York
Pages399-417
Number of pages19
ISBN (Electronic)9781461407393
ISBN (Print)9781461407386
DOIs
StatePublished - Jan 1 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

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