A realistic model of rod photoreceptor for use in a retina network model

Rodrigo Publio, Rodrigo F. Oliveira, Antonio C. Roque

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We propose a conductance-based model of a rod photoreceptor cell based on experimental data and other modeling works. In this model we use four types of ionic channels identified in the inner segment of the rod: nonselective cation channel (h), delayed rectifying potassium channel (Kv), noninactivating potassium channel (Kx) and calcium channel (Ca). The model accurately reproduces the rod response when fed with a simulated photocurrent signal. The results show that the initial transient in the voltage response is generated by the h channel. They also show that the h channel has a role in increasing the dynamic range of rod response to light intensity. Since we used a single compartment model and directly injected the photocurrent in this compartment instead of simulating the phototransduction process we produced a model with low computational cost to be used in large-scale retina models.

Original languageEnglish (US)
Pages (from-to)1020-1024
Number of pages5
JournalNeurocomputing
Volume69
Issue number10-12
DOIs
StatePublished - May 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence

Keywords

  • Dynamic range
  • Ion channels
  • Realistic modeling
  • Retina
  • Rod photoreceptor

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