Abstract
We propose a conductance-based model of a rod photoreceptor cell based on experimental data and other modeling works. In this model we use four types of ionic channels identified in the inner segment of the rod: nonselective cation channel (h), delayed rectifying potassium channel (Kv), noninactivating potassium channel (Kx) and calcium channel (Ca). The model accurately reproduces the rod response when fed with a simulated photocurrent signal. The results show that the initial transient in the voltage response is generated by the h channel. They also show that the h channel has a role in increasing the dynamic range of rod response to light intensity. Since we used a single compartment model and directly injected the photocurrent in this compartment instead of simulating the phototransduction process we produced a model with low computational cost to be used in large-scale retina models.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1020-1024 |
| Number of pages | 5 |
| Journal | Neurocomputing |
| Volume | 69 |
| Issue number | 10-12 |
| DOIs | |
| State | Published - May 2006 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Computer Science Applications
- Cognitive Neuroscience
- Artificial Intelligence
Keywords
- Dynamic range
- Ion channels
- Realistic modeling
- Retina
- Rod photoreceptor