Adaptive Doppler analysis for robust handheld optical coherence elastography

Farzana Zaki, Yahui Wang, Chizhong Wang, Xuan Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Optical coherence tomography (OCT) allows structural and functional imaging of biological tissue with high resolution and high speed. Optical coherence elastography (OCE), a functional extension of OCT, has been used to perform mechanical characterization. A handheld fiber-optic OCE instrument allows high sensitivity virtual palpation of tissue with great convenience and flexibility and can be used in a wide range of clinical settings. Moreover, fiber-optic OCE instruments can be integrated into a needle device to access deep tissue. However, the major challenge in the development of handheld OCE instrument is non-constant motion within the tissue. In this study, a simple and effective method for temporally and spatially adaptive Doppler analysis is investigated. The adaptive Doppler analysis method strategically chooses the time interval (δt) between signals involved in Doppler analysis, to track the motion speed v(z,t) that varies as time (t) and depth (z) in a deformed sample volume under manual compression. The aim is to use an optimal time interval to achieve a large yet artifact free Doppler phase shift for motion tracking.

Original languageEnglish (US)
Title of host publicationOptical Elastography and Tissue Biomechanics VI
EditorsGiuliano Scarcelli, Kirill V. Larin
ISBN (Electronic)9781510624023
StatePublished - 2019
EventOptical Elastography and Tissue Biomechanics VI 2019 - San Francisco, United States
Duration: Feb 2 2019Feb 3 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptical Elastography and Tissue Biomechanics VI 2019
Country/TerritoryUnited States
CitySan Francisco

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


  • Doppler
  • Optical coherence elastography
  • Optical coherence tomography
  • Optical sensing and sensors
  • Tissue characterization


Dive into the research topics of 'Adaptive Doppler analysis for robust handheld optical coherence elastography'. Together they form a unique fingerprint.

Cite this