Additive manufacturing of oral tablets: Technologies, materials and printed tablets

Alperen Abaci; Christina Gedeon; Anna Kuna; Murat Guvendiren

doi:10.3390/pharmaceutics13020156

Additive manufacturing of oral tablets: Technologies, materials and printed tablets

Alperen Abaci, Christina Gedeon, Anna Kuna, Murat Guvendiren

Chemical and Materials Engineering

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared to tablets manufactured using conventional approaches. Despite these advantages, AM has not yet become the mainstream manufacturing approach for fabrication of oral solid dosage forms mainly due to limitations of AM technologies and lack of diverse printable drug formulations. In this review, AM of oral tablets are summarized with respect to AM technology. A detailed review of AM methods and materials used for the AM of oral tablets is presented. This article also reviews the challenges in AM of pharmaceutical formulations and potential strategies to overcome these challenges.

Original language	English (US)
Article number	156
Pages (from-to)	1-27
Number of pages	27
Journal	Pharmaceutics
Volume	13
Issue number	2
DOIs	https://doi.org/10.3390/pharmaceutics13020156
State	Published - Jan 2021

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Keywords

3D printing
Drug delivery
Hydrogel
Pharmaceutical
Polymer
Precision medicine

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10.3390/pharmaceutics13020156

Cite this

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title = "Additive manufacturing of oral tablets: Technologies, materials and printed tablets",

abstract = "Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared to tablets manufactured using conventional approaches. Despite these advantages, AM has not yet become the mainstream manufacturing approach for fabrication of oral solid dosage forms mainly due to limitations of AM technologies and lack of diverse printable drug formulations. In this review, AM of oral tablets are summarized with respect to AM technology. A detailed review of AM methods and materials used for the AM of oral tablets is presented. This article also reviews the challenges in AM of pharmaceutical formulations and potential strategies to overcome these challenges.",

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AU - Abaci, Alperen

AU - Gedeon, Christina

AU - Kuna, Anna

AU - Guvendiren, Murat

PY - 2021/1

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AB - Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared to tablets manufactured using conventional approaches. Despite these advantages, AM has not yet become the mainstream manufacturing approach for fabrication of oral solid dosage forms mainly due to limitations of AM technologies and lack of diverse printable drug formulations. In this review, AM of oral tablets are summarized with respect to AM technology. A detailed review of AM methods and materials used for the AM of oral tablets is presented. This article also reviews the challenges in AM of pharmaceutical formulations and potential strategies to overcome these challenges.

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KW - Hydrogel

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KW - Polymer

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Additive manufacturing of oral tablets: Technologies, materials and printed tablets

Abstract

All Science Journal Classification (ASJC) codes

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