TY - JOUR
T1 - Age-dependent relationships between prefrontal cortex activation and processing efficiency
AU - Motes, Amichael A.
AU - Biswal, Bharat B.
AU - Rypma, Bart
N1 - Funding Information:
Correspondence should be addressed to: Michael A. Motes, Center for Brain Health, School of Behavioral & Brain Sciences, University of Texas at Dallas, 2200 W. Mockingbird, Dallas, TX 75235, USA. E-mail: [email protected] The project described was supported by Grants AG029523, NS049176, and AG032088 from NIH and Grant VA549-P-0027 from the United States Veterans Administration. The contents are solely the responsibility of the authors and do not necessarily represent the official views of NIH or the Veterans Administration.
PY - 2011/3
Y1 - 2011/3
N2 - Functional magnetic resonance imaging (fMRI) was used in the present study to examine the neural basis for agerelated differences in processing efficiency, particularly targeting prefrontal cortex (PFC). During scanning, older and younger participants completed a processing efficiency task in which they determined on each trial whether a symbol-number pair appeared in a simultaneously presented array of nine symbol-number pairs. Estimates of task-related blood-oxygen-level-dependent (BOLD) signal-change were obtained for each participant. These estimates were then correlated with the participants' performance on the task. For younger participants, BOLD signalchange within PFC decreased with better performance, but for older participants, BOLD signal-change within PFC increased with better performance. The results support the hypothesis that the availability and use of PFC resources mediate age-related changes in processing efficiency.
AB - Functional magnetic resonance imaging (fMRI) was used in the present study to examine the neural basis for agerelated differences in processing efficiency, particularly targeting prefrontal cortex (PFC). During scanning, older and younger participants completed a processing efficiency task in which they determined on each trial whether a symbol-number pair appeared in a simultaneously presented array of nine symbol-number pairs. Estimates of task-related blood-oxygen-level-dependent (BOLD) signal-change were obtained for each participant. These estimates were then correlated with the participants' performance on the task. For younger participants, BOLD signalchange within PFC decreased with better performance, but for older participants, BOLD signal-change within PFC increased with better performance. The results support the hypothesis that the availability and use of PFC resources mediate age-related changes in processing efficiency.
KW - Cognitive aging
KW - Individual differences
KW - Neuroimaging
KW - Prefrontal cortex
KW - Processing efficiency
UR - http://www.scopus.com/inward/record.url?scp=79551547075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551547075&partnerID=8YFLogxK
U2 - 10.1080/17588928.2010.512974
DO - 10.1080/17588928.2010.512974
M3 - Article
AN - SCOPUS:79551547075
SN - 1758-8928
VL - 2
SP - 1
EP - 10
JO - Cognitive Neuroscience
JF - Cognitive Neuroscience
IS - 1
ER -