Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP₃R)-gated intracellular calcium release

Keyphrases

• Alcohol-induced 100%
• Intracellular Calcium Release 100%
• Blood-brain Barrier Disruption 100%
• Human Brain Microvascular Endothelial Cells (HBMEC) 100%
• Inositol 1,4,5-trisphosphate Receptor (IP3R) 100%
• Ethanol 62%
• Myosin Light Chain Kinase 50%
• Blood-brain Barrier 37%
• Tight Junction Proteins 37%
• Metabolism 25%
• Leukocyte Migration 25%
• Phosphorylation 25%
• Endothelial Monolayer 25%
• Intracellular Ca2+ Release 25%
• Signaling Molecules 12%
• Alcohol 12%
• Intracellular Calcium 12%
• Neuropathology 12%
• Oxidative Stress 12%
• Ion Transport 12%
• Ca2+ 12%
• Stress-induced 12%
• Occludin 12%
• Alcoholism 12%
• Astrocytes 12%
• Structural Integrity 12%
• Leukocytes 12%
• Zonula occludens-1 (ZO-1) 12%
• Blood-brain Barrier Integrity 12%
• Functional Change 12%
• Tight Junction 12%
• Kinase Activation 12%
• Pericytes 12%
• Neuroinflammatory Disorders 12%
• Abusers 12%
• Claudin 12%
• Protein Loss 12%

Neuroscience

• Calcium Transport 100%
• Blood Brain Barrier 100%
• Inositol 1,4,5 Trisphosphate Receptor 100%
• Myosin Light-Chain Kinase 44%
• Tight Junction Protein 33%
• Metabolic Pathway 22%
• Tight Junction 22%
• Leukocyte Migration 22%
• Astrocyte 11%
• Occludin 11%
• Oxidative Stress 11%
• Leukocyte 11%
• Claudin 11%