This communication describes an integrated product recovery-cum-bioreactor based on an immobilized whole cell tubular reactor containing microporous hollow fiber membranes achieving simultaneous localized separation of the product by solvent extraction. The fermentor-extractor described here combines all the attractive features of a packed bed reactor (high cell density, cell retention, and high continuous production), while taking full advantage of the potential of membrane reactors for continuous integrated product recovery. The usual problems associated with membrane reactors have been eliminated. Specifically, the danger of fiber wall rupture due to cell growth into the fiber lumen, and excessive diffusional resistance of nutrients to, and product from, the cells have been avoided.
|Original language||English (US)|
|Title of host publication||Biotechnology Bioengineering Symposium|
|Publisher||John Wiley & Sons|
|Number of pages||11|
|State||Published - Dec 1 1985|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)