Alteration in dissolution characteristics of gelatin-containing formulations: A review of the problem, test methods, and solutions

Saranjit Singh, K. V.Rama Rao, K. Venugopal, R. Manikandan

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

The authors review the literature about the problem of the alteration in dissolution characteristics of gelatin-based formulations. This article also includes a brief introduction to gelatin as a pharmaceutical ingredient and describes examples of the altered dissolution profile; the established cause, mechanisms, influencing factors, and stress methods for study of the behavior; methods for determining the nature and extent of the change; and the reported solutions to the problem.

Original languageEnglish (US)
Pages (from-to)36-58
Number of pages23
JournalPharmaceutical Technology North America
Volume26
Issue number4
StatePublished - Aug 15 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Pharmaceutical Science

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