Altered white matter functional pathways in Alzheimer’s disease

Yilu Li, Jinzhong Peng, Zhenzhen Yang, Fanyu Zhang, Lin Liu, Pan Wang, Bharat B. Biswal

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Alzheimer’s disease (AD) is associated with functional disruption in gray matter (GM) and structural damage to white matter (WM), but the relationship to functional signal in WM is unknown. We performed the functional connectivity (FC) and graph theory analysis to investigate abnormalities of WM and GM functional networks and corpus callosum among different stages of AD from a publicly available dataset. Compared to the controls, AD group showed significantly decreased FC between the deep WM functional network (WM-FN) and the splenium of corpus callosum, between the sensorimotor/occipital WM-FN and GM visual network, but increased FC between the deep WM-FN and the GM sensorimotor network. In the clinical groups, the global assortativity, modular interaction between occipital WM-FN and visual network, nodal betweenness centrality, degree centrality, and nodal clustering coefficient in WM- and GM-FNs were reduced. However, modular interaction between deep WM-FN and sensorimotor network, and participation coefficients of deep WM-FN and splenium of corpus callosum were increased. These findings revealed the abnormal integration of functional networks in different stages of AD from a novel WM-FNs perspective. The abnormalities of WM functional pathways connect downward to the corpus callosum and upward to the GM are correlated with AD.

Original languageEnglish (US)
Article numberbhad505
JournalCerebral Cortex
Issue number3
StatePublished - Mar 1 2024

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


  • Alzheimer’s disease
  • corpus callosum
  • functional connectivity
  • graph theory
  • white matter


Dive into the research topics of 'Altered white matter functional pathways in Alzheimer’s disease'. Together they form a unique fingerprint.

Cite this