Amplifying the red-emission of upconverting nanoparticles for biocompatible clinically used prodrug-induced photodynamic therapy

Amol Punjabi, Xiang Wu, Amira Tokatli-Apollon, Mahmoud El-Rifai, Hyungseok Lee, Yuanwei Zhang, Chao Wang, Zhuang Liu, Emory M. Chan, Chunying Duan, Gang Han

Research output: Contribution to journalArticlepeer-review

216 Scopus citations

Abstract

A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal β-phase core/shell UCNPs. When conjugated to aminolevulinic acid, a clinically used photodynamic therapy (PDT) prodrug, significant PDT effect in tumor was demonstrated in a deep-tissue (>1.2 cm) setting in vivo at a biocompatible laser power density. Furthermore, we show that our UCNP-PDT system with NIR irradiation outperforms clinically used red light irradiation in a deep tumor setting in vivo. This study marks a major step forward in photodynamic therapy utilizing UCNPs to effectively access deep-set tumors. It also provides an opportunity for the wide application of upconverting red radiation in photonics and biophotonics.

Original languageEnglish (US)
Pages (from-to)10621-10630
Number of pages10
JournalACS Nano
Volume8
Issue number10
DOIs
StatePublished - Oct 28 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Keywords

  • nanoparticles
  • photodynamic therapy
  • prodrug
  • red-emission
  • upconverting

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