An analytical solution for percutaneous drug absorption

L. Simon, N. W. Loney

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Laplace transforms were used to solve a mathematical model developed for percutaneous drug absorption. The model includes application and removal of the vehicle from the skin. A system of two linear partial differential equations was solved during the application period. The concentration of the medicinal agent in the skin at the end of the application period was then used as initial condition to determine the distribution of the drug in the skin following instantaneous removal of the vehicle. Numerical results of the amount of drug released in both cases are presented.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE 29th Annual Northeast Bioengineering Conference
EditorsStanley Reisman, Richard Foulds, Bruno Mantilla
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages303-304
Number of pages2
ISBN (Electronic)0780377672
DOIs
StatePublished - Jan 1 2003
Event29th IEEE Annual Northeast Bioengineering Conference, NEBC 2003 - Newark, United States
Duration: Mar 22 2003Mar 23 2003

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
Volume2003-January
ISSN (Print)1071-121X
ISSN (Electronic)2160-7001

Other

Other29th IEEE Annual Northeast Bioengineering Conference, NEBC 2003
CountryUnited States
CityNewark
Period3/22/033/23/03

All Science Journal Classification (ASJC) codes

  • Bioengineering

Keywords

  • Absorption
  • Biomembranes
  • Boundary conditions
  • Chemical engineering
  • Chemical technology
  • Drugs
  • Equations
  • In vitro
  • Skin
  • Vehicles

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