An electroactive conduit for spinal cord injury repair

Y. S. Lee, C. Ezebuiroh, C. Collins, T. L. Arinzeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Electrospun fibrous scaffolds of piezoelectric polyvinylidene fluoride-trifluoroethylene (PVD F -TrFE) were evaluated to enhance neurite extension for spinal cord injury (SCI) repair. An aligned fibrous piezoelectric scaffold was investigated in order to provide physical cues (via contact guidance) and local electrical activity to promote neuronal differentiation and neurite extension. Rat pheochromocytoma (PC12) and dorsal root ganglion explants (DRGs) were cultured on random or aligned fibrous PVDF-TrFE scaffolds. Neurites of PC12 cells were observed to extend and proliferated along the direction of the aligned fibers. Neurite extension of DRGs was observed on both random and aligned electrospun PVDF-TrFE scaffolds suggesting the potential use of these scaffolds in spinal cord repair.

Original languageEnglish (US)
Title of host publicationNEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781424443628
DOIs
StatePublished - 2009
EventIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States
Duration: Apr 3 2009Apr 5 2009

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN (Print)1071-121X

Other

OtherIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
Country/TerritoryUnited States
CityBoston, MA
Period4/3/094/5/09

All Science Journal Classification (ASJC) codes

  • Bioengineering

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