Abstract
Electrospun fibrous scaffolds of piezoelectric polyvinylidene fluoride-trifluoroethylene (PVD F -TrFE) were evaluated to enhance neurite extension for spinal cord injury (SCI) repair. An aligned fibrous piezoelectric scaffold was investigated in order to provide physical cues (via contact guidance) and local electrical activity to promote neuronal differentiation and neurite extension. Rat pheochromocytoma (PC12) and dorsal root ganglion explants (DRGs) were cultured on random or aligned fibrous PVDF-TrFE scaffolds. Neurites of PC12 cells were observed to extend and proliferated along the direction of the aligned fibers. Neurite extension of DRGs was observed on both random and aligned electrospun PVDF-TrFE scaffolds suggesting the potential use of these scaffolds in spinal cord repair.
Original language | English (US) |
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Title of host publication | NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference |
DOIs | |
State | Published - Sep 21 2009 |
Event | IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States Duration: Apr 3 2009 → Apr 5 2009 |
Publication series
Name | Bioengineering, Proceedings of the Northeast Conference |
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ISSN (Print) | 1071-121X |
Other
Other | IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 |
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Country | United States |
City | Boston, MA |
Period | 4/3/09 → 4/5/09 |
All Science Journal Classification (ASJC) codes
- Bioengineering