An evaluation of the osteoinductive properties of bioactive composites

Ajitha Pattella, Treena Livingston Arinzeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

The two most widely investigated materials for bone repair are β-tricalcium phosphate (β-TCP) (Ca3(P04)2) and synthetic hydroxyapatite (HA) (Ca10(PO4)6(OH) 2). They are bioactive as well as biocompatible and osteoconductive [1]. These materials are categorized as bioactive because they have the ability to form strong chemical bond with the neighboring bone tissue. Clinically, however, these materials have had limited use because of their brittleness and difficulty in shaping [2]. Therefore, biodegradable polymer/bioceramic composites have been sought as an alternative form to using calcium phosphates alone. In this study, composites consisting of 20/80 HA/TCP and poly (ε-caprolactone) (PCL) were fabricated using the electrospinning technique. Electrospun ceramic composites were fabricated with two different architectures and evaluated for bioactivity and osteogenic properties. The results suggested that composites consisting of both nano and mirconscale fiber morphologies had better bioactivity and osteogenic properties.

Original languageEnglish (US)
Title of host publicationProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
DOIs
StatePublished - Jun 8 2010
Event36th Annual Northeast Bioengineering Conference, NEBEC 2010 - New York, NY, United States
Duration: Mar 26 2010Mar 28 2010

Publication series

NameProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010

Other

Other36th Annual Northeast Bioengineering Conference, NEBEC 2010
Country/TerritoryUnited States
CityNew York, NY
Period3/26/103/28/10

All Science Journal Classification (ASJC) codes

  • Bioengineering

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