TY - GEN
T1 - An evaluation of the osteoinductive properties of bioactive composites
AU - Pattella, Ajitha
AU - Arinzeh, Treena Livingston
PY - 2010
Y1 - 2010
N2 - The two most widely investigated materials for bone repair are β-tricalcium phosphate (β-TCP) (Ca3(P04)2) and synthetic hydroxyapatite (HA) (Ca10(PO4)6(OH) 2). They are bioactive as well as biocompatible and osteoconductive [1]. These materials are categorized as bioactive because they have the ability to form strong chemical bond with the neighboring bone tissue. Clinically, however, these materials have had limited use because of their brittleness and difficulty in shaping [2]. Therefore, biodegradable polymer/bioceramic composites have been sought as an alternative form to using calcium phosphates alone. In this study, composites consisting of 20/80 HA/TCP and poly (ε-caprolactone) (PCL) were fabricated using the electrospinning technique. Electrospun ceramic composites were fabricated with two different architectures and evaluated for bioactivity and osteogenic properties. The results suggested that composites consisting of both nano and mirconscale fiber morphologies had better bioactivity and osteogenic properties.
AB - The two most widely investigated materials for bone repair are β-tricalcium phosphate (β-TCP) (Ca3(P04)2) and synthetic hydroxyapatite (HA) (Ca10(PO4)6(OH) 2). They are bioactive as well as biocompatible and osteoconductive [1]. These materials are categorized as bioactive because they have the ability to form strong chemical bond with the neighboring bone tissue. Clinically, however, these materials have had limited use because of their brittleness and difficulty in shaping [2]. Therefore, biodegradable polymer/bioceramic composites have been sought as an alternative form to using calcium phosphates alone. In this study, composites consisting of 20/80 HA/TCP and poly (ε-caprolactone) (PCL) were fabricated using the electrospinning technique. Electrospun ceramic composites were fabricated with two different architectures and evaluated for bioactivity and osteogenic properties. The results suggested that composites consisting of both nano and mirconscale fiber morphologies had better bioactivity and osteogenic properties.
UR - http://www.scopus.com/inward/record.url?scp=77953068140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953068140&partnerID=8YFLogxK
U2 - 10.1109/NEBC.2010.5458204
DO - 10.1109/NEBC.2010.5458204
M3 - Conference contribution
AN - SCOPUS:77953068140
SN - 9781424468799
T3 - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
BT - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
T2 - 36th Annual Northeast Bioengineering Conference, NEBEC 2010
Y2 - 26 March 2010 through 28 March 2010
ER -