TY - JOUR
T1 - An Extended Duration Operation for Porous Hollow Fiber-Based Antisolvent Crystallization
AU - Zhou, Xinyi
AU - Wang, Bing
AU - Liu, Qiuhong
AU - Liu, Chen
AU - Gao, Xuemin
AU - Sirkar, Kamalesh K.
AU - Chen, Dengyue
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/7/10
Y1 - 2019/7/10
N2 - Poor aqueous solubility of numerous active pharmaceutical ingredients has raised considerable concern about the bioavailability of drugs. A porous hollow fiber antisolvent crystallization (PHFAC) device was designed to continuously produce drug nanocrystals under ambient conditions. The drug solution pumped into the shell side of the module encountered jets of antisolvent deionized water from tiny pores on the hollow fiber walls inducing a high degree of supersaturation as well as crystallization of the obtained nanoparticles. To study the effect of duration of operation for the PHFAC module and the stability of the nanocrystal production, a larger-scale and a smaller-scale module were designed to compare the nanocrystals in a 60 min long experiment. The characterized results showed that the nanocrystals were stable in size and morphology, and the nanocrystals produced by the larger-scale module presented no difference from those of the small-scale module. Meanwhile, the drug nanoparticles remained unchanged for the 28 days during repeated production, indicating excellent stability. It appears possible that the experiment could be scaled up to bring the application to industrial practice.
AB - Poor aqueous solubility of numerous active pharmaceutical ingredients has raised considerable concern about the bioavailability of drugs. A porous hollow fiber antisolvent crystallization (PHFAC) device was designed to continuously produce drug nanocrystals under ambient conditions. The drug solution pumped into the shell side of the module encountered jets of antisolvent deionized water from tiny pores on the hollow fiber walls inducing a high degree of supersaturation as well as crystallization of the obtained nanoparticles. To study the effect of duration of operation for the PHFAC module and the stability of the nanocrystal production, a larger-scale and a smaller-scale module were designed to compare the nanocrystals in a 60 min long experiment. The characterized results showed that the nanocrystals were stable in size and morphology, and the nanocrystals produced by the larger-scale module presented no difference from those of the small-scale module. Meanwhile, the drug nanoparticles remained unchanged for the 28 days during repeated production, indicating excellent stability. It appears possible that the experiment could be scaled up to bring the application to industrial practice.
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U2 - 10.1021/acs.iecr.9b02028
DO - 10.1021/acs.iecr.9b02028
M3 - Article
AN - SCOPUS:85068430972
SN - 0888-5885
VL - 58
SP - 12431
EP - 12437
JO - Industrial and Engineering Chemistry Research
JF - Industrial and Engineering Chemistry Research
IS - 27
ER -