An in vitro uniaxial stretch model for axonal injury

Bryan J. Pfister, Timothy P. Weihs, Michael Betenbaugh, Gang Bao

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

A uniaxial stretching device was developed to better tudy neural cell death due to traumatic head injury. Using displacement control rather than force control, this device was capable of achieving strains >70% and strain rates up to 90 s-1. It was demonstrated that the prespecified displacement profiles can be realized almost precisely, and the stretching deformation generated by the device was uniaxial, uniform, and highly reproducible.

Original languageEnglish (US)
Pages (from-to)589-598
Number of pages10
JournalAnnals of Biomedical Engineering
Volume31
Issue number5
DOIs
StatePublished - 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Keywords

  • Biomechanics
  • Diffuse axonal injury
  • Neural cell death
  • Traumatic brain injury
  • Uniaxial stretch

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