An in vitro uniaxial stretch model for axonal injury

Bryan J. Pfister; Timothy P. Weihs; Michael Betenbaugh; Gang Bao

doi:10.1114/1.1566445

An in vitro uniaxial stretch model for axonal injury

Bryan J. Pfister
, Timothy P. Weihs
, Michael Betenbaugh
, Gang Bao

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

A uniaxial stretching device was developed to better tudy neural cell death due to traumatic head injury. Using displacement control rather than force control, this device was capable of achieving strains >70% and strain rates up to 90 s^-1. It was demonstrated that the prespecified displacement profiles can be realized almost precisely, and the stretching deformation generated by the device was uniaxial, uniform, and highly reproducible.

Original language	English (US)
Pages (from-to)	589-598
Number of pages	10
Journal	Annals of Biomedical Engineering
Volume	31
Issue number	5
DOIs	https://doi.org/10.1114/1.1566445
State	Published - 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biomedical Engineering

Keywords

Biomechanics
Diffuse axonal injury
Neural cell death
Traumatic brain injury
Uniaxial stretch

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10.1114/1.1566445

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title = "An in vitro uniaxial stretch model for axonal injury",

abstract = "A uniaxial stretching device was developed to better tudy neural cell death due to traumatic head injury. Using displacement control rather than force control, this device was capable of achieving strains >70\% and strain rates up to 90 s-1. It was demonstrated that the prespecified displacement profiles can be realized almost precisely, and the stretching deformation generated by the device was uniaxial, uniform, and highly reproducible.",

keywords = "Biomechanics, Diffuse axonal injury, Neural cell death, Traumatic brain injury, Uniaxial stretch",

author = "Pfister, \{Bryan J.\} and Weihs, \{Timothy P.\} and Michael Betenbaugh and Gang Bao",

note = "Funding Information: ments on a draft of this manuscript. B.J.P. was supported in part by a fellowship provided by the Johns Hopkins University Applied Physics Laboratory. B.J.P. would also like to thank Jack Roberts for his encouragement, support, and assistance.",

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AU - Pfister, Bryan J.

AU - Weihs, Timothy P.

AU - Betenbaugh, Michael

AU - Bao, Gang

N1 - Funding Information: ments on a draft of this manuscript. B.J.P. was supported in part by a fellowship provided by the Johns Hopkins University Applied Physics Laboratory. B.J.P. would also like to thank Jack Roberts for his encouragement, support, and assistance.

PY - 2003

Y1 - 2003

N2 - A uniaxial stretching device was developed to better tudy neural cell death due to traumatic head injury. Using displacement control rather than force control, this device was capable of achieving strains >70% and strain rates up to 90 s-1. It was demonstrated that the prespecified displacement profiles can be realized almost precisely, and the stretching deformation generated by the device was uniaxial, uniform, and highly reproducible.

AB - A uniaxial stretching device was developed to better tudy neural cell death due to traumatic head injury. Using displacement control rather than force control, this device was capable of achieving strains >70% and strain rates up to 90 s-1. It was demonstrated that the prespecified displacement profiles can be realized almost precisely, and the stretching deformation generated by the device was uniaxial, uniform, and highly reproducible.

KW - Biomechanics

KW - Diffuse axonal injury

KW - Neural cell death

KW - Traumatic brain injury

KW - Uniaxial stretch

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JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

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ER -

An in vitro uniaxial stretch model for axonal injury

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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