TY - JOUR
T1 - Analysis of cross-correlations in electroencephalogram signals as an approach to proactive diagnosis of schizophrenia
AU - Timashev, Serge F.
AU - Panischev, Oleg Yu
AU - Polyakov, Yuriy S.
AU - Demin, Sergey A.
AU - Kaplan, Alexander Ya
N1 - Funding Information:
The authors are grateful to A.F. Iznak, N.L. Gorbachevskiy, and I.A. Kozlova at the National Center for Psychiatric Health of the Russian Academy of Medical Sciences for the EEG signal recordings analyzed in this study. This work was partially supported by the Russian Foundation for Basic Research, grant nos. 09-04-12094-ofi_m, 10-02-01346-a, 11-02-00540-a; Russian Humanities Scientific Fund, grant no. 09-06-00671-a.
PY - 2012/2/15
Y1 - 2012/2/15
N2 - We apply flicker-noise spectroscopy (FNS), a time series analysis method operating on structure functions and power spectrum estimates, to study the clinical electroencephalogram (EEG) signals recorded in children/adolescents (11 to 14 years of age) with diagnosed schizophrenia-spectrum symptoms at the National Center for Psychiatric Health (NCPH) of the Russian Academy of Medical Sciences. The EEG signals for these subjects were compared with the signals for a control sample of chronically depressed children/adolescents. The purpose of the study is to look for diagnostic signs of subjects' susceptibility to schizophrenia in the FNS parameters for specific electrodes and cross-correlations between the signals simultaneously measured at different points on the scalp. Our analysis of EEG signals from scalp-mounted electrodes at locations F3 and F4, which are symmetrically positioned in the left and right frontal areas of cerebral cortex, respectively, demonstrates an essential role of frequencyphase synchronization, a phenomenon representing specific correlations between the characteristic frequencies and phases of excitations in the brain. We introduce quantitative measures of frequencyphase synchronization and systematize the values of FNS parameters for the EEG data. The comparison of our results with the medical diagnoses for 84 subjects performed at NCPH makes it possible to group the EEG signals into 4 categories corresponding to different risk levels of subjects' susceptibility to schizophrenia. We suggest that the introduced quantitative characteristics and classification of cross-correlations may be used for the diagnosis of schizophrenia at the early stages of its development.
AB - We apply flicker-noise spectroscopy (FNS), a time series analysis method operating on structure functions and power spectrum estimates, to study the clinical electroencephalogram (EEG) signals recorded in children/adolescents (11 to 14 years of age) with diagnosed schizophrenia-spectrum symptoms at the National Center for Psychiatric Health (NCPH) of the Russian Academy of Medical Sciences. The EEG signals for these subjects were compared with the signals for a control sample of chronically depressed children/adolescents. The purpose of the study is to look for diagnostic signs of subjects' susceptibility to schizophrenia in the FNS parameters for specific electrodes and cross-correlations between the signals simultaneously measured at different points on the scalp. Our analysis of EEG signals from scalp-mounted electrodes at locations F3 and F4, which are symmetrically positioned in the left and right frontal areas of cerebral cortex, respectively, demonstrates an essential role of frequencyphase synchronization, a phenomenon representing specific correlations between the characteristic frequencies and phases of excitations in the brain. We introduce quantitative measures of frequencyphase synchronization and systematize the values of FNS parameters for the EEG data. The comparison of our results with the medical diagnoses for 84 subjects performed at NCPH makes it possible to group the EEG signals into 4 categories corresponding to different risk levels of subjects' susceptibility to schizophrenia. We suggest that the introduced quantitative characteristics and classification of cross-correlations may be used for the diagnosis of schizophrenia at the early stages of its development.
KW - Cross-correlations
KW - Electroencephalogram signals
KW - Flicker-noise spectroscopy
KW - Frequencyphase synchronization
KW - Schizophrenia
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U2 - 10.1016/j.physa.2011.09.032
DO - 10.1016/j.physa.2011.09.032
M3 - Article
AN - SCOPUS:84655164995
SN - 0378-4371
VL - 391
SP - 1179
EP - 1194
JO - Physica A: Statistical Mechanics and its Applications
JF - Physica A: Statistical Mechanics and its Applications
IS - 4
ER -