Angiogenic Self-Assembling Peptide Scaffolds for Functional Tissue Regeneration

Biplab Sarkar, Peter K. Nguyen, William Gao, Akhil Dondapati, Zain Siddiqui, Vivek A. Kumar

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Implantation of acellular biomimetic scaffolds with proangiogenic motifs may have exciting clinical utility for the treatment of ischemic pathologies such as myocardial infarction. Although direct delivery of angiogenic proteins is a possible treatment option, smaller synthetic peptide-based nanostructured alternatives are being investigated due to favorable factors, such as sustained efficacy and high-density epitope presentation of functional moieties. These peptides may be implanted in vivo at the site of ischemia, bypassing the first-pass metabolism and enabling long-term retention and sustained efficacy. Mimics of angiogenic proteins show tremendous potential for clinical use. We discuss possible approaches to integrate the functionality of such angiogenic peptide mimics into self-assembled peptide scaffolds for application in functional tissue regeneration.

Original languageEnglish (US)
Pages (from-to)3597-3611
Number of pages15
JournalBiomacromolecules
Volume19
Issue number9
DOIs
StatePublished - Sep 10 2018

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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