TY - JOUR
T1 - Antimicrobial and Anticancer Activity of a Novel Peptide (Musterolysin) Extracted from Slurry of Mustard Oil Refinery Industry
AU - Mondal, Suresh K.
AU - Perumal, Venkatesan
AU - Das, Radharani
AU - Roymahapatra, Gourishankar
AU - Mandal, Santi M.
N1 - Publisher Copyright:
© Engineered Science Publisher LLC 2022.
PY - 2022/12
Y1 - 2022/12
N2 - Bacterial infections and cancer have been most prevalent diseases throughout the World. The discovery and development of new antibacterial and anticancer agents is critical. If such a valuable medicinal product is created from waste resources from the oil refinery business, academicians and industrialists will pay close attention. The sequential extraction process followed by RP-HPLCfractions was used to purify and identify a new peptide from mustard oil refinery sludge. The sequence of the peptide was determined as NH2-KYQFFVP-COOH using MALDI TOF/TOF Mass spectrometry. The antibacterial activity of the peptide was determined against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, and Bacillus subtilis. The proapoptotic activity of the peptide was also determined against Hep2 (Human epidermoid cancer cell line). These findings suggest that readily available bio-waste might be a novel source of bioactive antibacterial and proapoptotic lipopeptides.
AB - Bacterial infections and cancer have been most prevalent diseases throughout the World. The discovery and development of new antibacterial and anticancer agents is critical. If such a valuable medicinal product is created from waste resources from the oil refinery business, academicians and industrialists will pay close attention. The sequential extraction process followed by RP-HPLCfractions was used to purify and identify a new peptide from mustard oil refinery sludge. The sequence of the peptide was determined as NH2-KYQFFVP-COOH using MALDI TOF/TOF Mass spectrometry. The antibacterial activity of the peptide was determined against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, and Bacillus subtilis. The proapoptotic activity of the peptide was also determined against Hep2 (Human epidermoid cancer cell line). These findings suggest that readily available bio-waste might be a novel source of bioactive antibacterial and proapoptotic lipopeptides.
KW - Antibacterial activity
KW - Bioactive lipopeptide
KW - Mustard oil slurry
KW - Proapoptotic activity
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U2 - 10.30919/esfaf776
DO - 10.30919/esfaf776
M3 - Article
AN - SCOPUS:85150938842
SN - 2687-7295
VL - 10
SP - 24
EP - 29
JO - ES Food and Agroforestry
JF - ES Food and Agroforestry
ER -