Aspartic acid racemization on aging

Sara C. Zapico, Christian Thomas, Sofía Tirados Menéndez

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Leon Trotsky said, “old age is the most unexpected of all the things that can happen to a man”,1 but it seems difficult to believe as the process of growing old is accompanied by a plethora of physical signs, which can be easily recognised. The progressive appearance of wrinkles and grey hair as well as changes in height, vision or hearing are the detectable consequences of the cellular and molecular changes taking place in our organism as years go by. Different mechanisms are considered hallmarks of aging like genomic instability, stem cell exhaustion or telomere attrition (Lopez-Otin et al. 2013). Among them, proteostasis is defined as a state of dynamic equilibrium in which protein stability and functionality is preserved, all thanks to a complex network of processes designed to control the fate of a protein from synthesis to degradation (Balch et al. 2008). Unfortunately, these mechanisms cannot completely avoid the accumulation of unwanted protein products and it is becoming clear that proteostasis malfunction has a key role in aging and its related disorders (Taylor and Dillin 2011).

Original languageEnglish (US)
Title of host publicationMechanisms Linking Aging, Diseases and Biological Age Estimation
PublisherCRC Press
Number of pages10
ISBN (Electronic)9781498709705
ISBN (Print)9781498709699
StatePublished - Jan 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Social Sciences
  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


  • Aging
  • Aspartic acid
  • Elastin
  • Erythrocytes
  • Eye lens
  • Protein turnover
  • Racemization


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