Associations between physical fitness and cerebellar gray matter volume in adolescents

Petri Jalanko, Laura Säisänen, Elisa Kallioniemi, Mervi Könönen, Timo A. Lakka, Sara Määttä, Eero A. Haapala

Research output: Contribution to journalArticlepeer-review

Abstract

Despite the importance of the developing cerebellum on cognition, the associations between physical fitness and cerebellar volume in adolescents remain unclear. We explored the associations of physical fitness with gray matter (GM) volume of VI, VIIb and Crus I & II, which are cerebellar lobules related to cognition, in 40 (22 females; 17.9 ± 0.8 year-old) adolescents, and whether the associations were sex-specific. Peak oxygen uptake (V̇O2peak) and power were assessed by maximal ramp test on a cycle ergometer, muscular strength with standing long jump (SLJ), speed-agility with the shuttle-run test (SRT), coordination with the Box and Block Test (BBT) and neuromuscular performance index (NPI) as the sum of SLJ, BBT and SRT z-scores. Body composition was measured using a dual-energy X-ray absorptiometry. Cerebellar volumes were assessed by magnetic resonance imaging. V̇O2peak relative to lean mass was inversely associated with the GM volume of the cerebellum (standardized regression coefficient (β) = −0.038, 95% confidence interval (CI) -0.075 to 0.001, p = 0.044). Cumulative NPI was positively associated with the GM volume of Crus I (β = 0.362, 95% CI 0.045 to 0.679, p = 0.027). In females, better performance in SRT was associated with a larger GM volume of Crus I (β = −0.373, 95% CI -0.760 to −0.028, p = 0.036). In males, cumulative NPI was inversely associated with the GM volume of Crus II (β = −0.793, 95% CI -1.579 to −0.008 p = 0.048). Other associations were nonsignificant. In conclusion, cardiorespiratory fitness, neuromuscular performance and speed-agility were associated with cerebellar GM volume, and the strength and direction of associations were sex-specific.

Original languageEnglish (US)
Article numbere14513
JournalScandinavian Journal of Medicine and Science in Sports
Volume34
Issue number1
DOIs
StatePublished - Jan 2024

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Keywords

  • cardiorespiratory fitness
  • cerebellum
  • coordination
  • gray matter
  • MRI
  • muscular strength
  • speed

Fingerprint

Dive into the research topics of 'Associations between physical fitness and cerebellar gray matter volume in adolescents'. Together they form a unique fingerprint.

Cite this