Asymmetric functionalization of gold nanoparticles with oligonucleotides

Xiaoyang Xu, Nathaniel L. Rosi, Yuhuang Wang, Fengwei Huo, Chad A. Mirkin

Research output: Contribution to journalArticlepeer-review

329 Scopus citations


Gold nanoparticles (AuNPs) were anisotropically functionalized with two different oligonucleotide sequences using magnetic microparticles as geometric restriction templates for site-selective enzymatic extension of particle-bound oligonucleotides. The divalent linking capability of the resulting AuNPs allowed for the design and programmable assembly of discrete nanoparticle heterostructures.

Original languageEnglish (US)
Pages (from-to)9286-9287
Number of pages2
JournalJournal of the American Chemical Society
Issue number29
StatePublished - Jul 26 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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