Atomic force microscope infrared spectroscopy of griseofulvin nanocrystals

Aaron J. Harrison, Ecevit A. Bilgili, Stephen P. Beaudoin, Lynne S. Taylor

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The goal of this work was to evaluate the ability of photothermal-induced resonance (PTIR) to measure the local infrared absorption spectra of crystalline organic drug nanoparticles embedded within solid matrices. Herein, the first reports of the chemical characterization of sub-100 nm organic crystals are described; infrared spectra of 90 nm griseofulvin particles were obtained, confirming the chemical resolution of PTIR beyond the diffraction limit. Additionally, particle size distributions via dynamic light scattering and PTIR image analysis were found to be similar, suggesting that the PTIR measurements are not significantly affected by inhomogeneous infrared absorptivity of this system. Thus as medical applications increasingly emphasize localized drug delivery via micro/nanoengineered structures, PTIR can be used to unambiguously chemically characterize drug formulations at these length scales.

Original languageEnglish (US)
Pages (from-to)11449-11455
Number of pages7
JournalAnalytical Chemistry
Volume85
Issue number23
DOIs
StatePublished - Dec 3 2013

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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