TY - GEN
T1 - Benefits of using paired controls for analyzing gene expression of prostate cancer
AU - Haney, Scott
AU - Kam, Moshe
AU - Hrebien, Leonid
PY - 2008
Y1 - 2008
N2 - The genetics of prostate cancer are highly variable and not well understood. No consistent pattern of mutations across prostate cancer samples has yet been found. Due to this inherent heterogeneity it is natural to wonder whether or not using paired controls in gene expression studies might be useful. Although other studies have previously analyzed the use of paired controls for the expression of a handful of genes at a time no study has yet been performed to assess the benefits of using paired controls rather than independent controls on a large scale. By using a prostate cancer microarray data set that consisted of 58 pairs of paired cancer and control samples as well as 18 independent controls we found that searches for differentially expressed genes and for upregulated genes were significantly enhanced by using paired controls instead of independent controls.
AB - The genetics of prostate cancer are highly variable and not well understood. No consistent pattern of mutations across prostate cancer samples has yet been found. Due to this inherent heterogeneity it is natural to wonder whether or not using paired controls in gene expression studies might be useful. Although other studies have previously analyzed the use of paired controls for the expression of a handful of genes at a time no study has yet been performed to assess the benefits of using paired controls rather than independent controls on a large scale. By using a prostate cancer microarray data set that consisted of 58 pairs of paired cancer and control samples as well as 18 independent controls we found that searches for differentially expressed genes and for upregulated genes were significantly enhanced by using paired controls instead of independent controls.
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U2 - 10.1109/BIBE.2008.4696742
DO - 10.1109/BIBE.2008.4696742
M3 - Conference contribution
AN - SCOPUS:67549129339
SN - 9781424428458
T3 - 8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008
BT - 8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008
T2 - 8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008
Y2 - 8 October 2008 through 10 October 2008
ER -