Bioprinters for organs-on-chips

Amir K. Miri, Ebrahim Mostafavi, Danial Khorsandi, Shu Kai Hu, Matthew Malpica, Ali Khademhosseini

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Recent advances in bioprinting technologies have enabled rapid manufacturing of organ-on-chip models along with biomimetic tissue microarchitectures. Bioprinting techniques can be used to integrate microfluidic channels and flow connections in organ-on-chip models. We review bioprinters in two categories of nozzle-based and optical-based methods, and then discuss their fabrication parameters such as resolution, replication fidelity, fabrication time, and cost for micro-tissue models and microfluidic applications. The use of bioprinters has shown successful replicates of functional engineered tissue models integrated within a desired microfluidic system, which facilitates the observation of metabolism or secretion of models and sophisticated control of a dynamic environment. This may provide a wider order of tissue engineering fabrication in mimicking physiological conditions for enhancing further applications such as drug development and pathological studies.

Original languageEnglish (US)
Article number042002
Issue number4
StatePublished - Sep 20 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering


  • bioprinting
  • microfluidics
  • multiscale
  • organ-on-chip


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