Biphasic calcium phosphate ceramics for bone regeneration and tissue engineering applications

Sonja Ellen Lobo, Treena Livingston Arinzeh

Research output: Contribution to journalArticlepeer-review

166 Scopus citations


Biphasic calcium phosphates (BCP) have been sought after as biomaterials for the reconstruction of bone defects in maxillofacial, dental and orthopaedic applications. They have demonstrated proven biocompatibility, osteoconductivity, safety and predictability in in vitro, in vivo and clinical models. More recently, in vitro and in vivo studies have shown that BCP can be osteoinductive. In the field of tissue engineering, they represent promising scaffolds capable of carrying and modulating the behavior of stem cells. This review article will highlight the latest advancements in the use of BCP and the characteristics that create a unique microenvironment that favors bone regeneration

Original languageEnglish (US)
Pages (from-to)815-826
Number of pages12
Issue number2
StatePublished - 2010

All Science Journal Classification (ASJC) codes

  • General Materials Science


  • Bone reconstruction
  • Calcium phosphate ceramics
  • Stem cell
  • Tissue engineering


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