TY - JOUR
T1 - Bitter taste receptors (T2Rs) are sentinels that coordinate metabolic and immunological defense responses
AU - Harmon, Caroline P.
AU - Deng, Daiyong
AU - Breslin, Paul AS
N1 - Publisher Copyright:
© 2021
PY - 2021/4
Y1 - 2021/4
N2 - In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.
AB - In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.
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U2 - 10.1016/j.cophys.2021.01.006
DO - 10.1016/j.cophys.2021.01.006
M3 - Review article
AN - SCOPUS:85099657147
SN - 2468-8681
VL - 20
SP - 70
EP - 76
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
ER -