Bitter taste receptors (T2Rs) are sentinels that coordinate metabolic and immunological defense responses

Caroline P. Harmon; Daiyong Deng; Paul AS Breslin

doi:10.1016/j.cophys.2021.01.006

Bitter taste receptors (T2Rs) are sentinels that coordinate metabolic and immunological defense responses

Caroline P. Harmon
, Daiyong Deng
, Paul AS Breslin

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.

Original language	English (US)
Pages (from-to)	70-76
Number of pages	7
Journal	Current Opinion in Physiology
Volume	20
DOIs	https://doi.org/10.1016/j.cophys.2021.01.006
State	Published - Apr 2021
Externally published	Yes

All Science Journal Classification (ASJC) codes

Physiology
Physiology (medical)

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10.1016/j.cophys.2021.01.006

Cite this

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abstract = "In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.",

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AU - Harmon, Caroline P.

AU - Deng, Daiyong

AU - Breslin, Paul AS

PY - 2021/4

Y1 - 2021/4

N2 - In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.

AB - In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.

UR - https://www.scopus.com/pages/publications/85099657147

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U2 - 10.1016/j.cophys.2021.01.006

DO - 10.1016/j.cophys.2021.01.006

M3 - Review article

AN - SCOPUS:85099657147

SN - 2468-8681

VL - 20

SP - 70

EP - 76

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

ER -

Bitter taste receptors (T2Rs) are sentinels that coordinate metabolic and immunological defense responses

Abstract

All Science Journal Classification (ASJC) codes

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