Blood oxygen saturation estimation in transilluminated images of skin lesions

Brian D'Alessandro, Atam P. Dhawan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Estimating the oxygen saturation of blood surrounding skin lesions is critical for the early detection of skin cancer and malignancy such as melanoma. Through multispectral transillumination of the skin, a set of images can be obtained which helps visualize areas of subsurface absorption due to chromophores such as melanin, hemoglobin, and deoxyhemoglobin. To relate pixel intensity in these images to spatially located absorption coefficient values, we develop a correction factor to Beer's law, estimated through a Monte Carlo simulation of light propagation in skin, which takes into account the specific geometry of our transillumination imaging apparatus. We then use this relation on the multispectral imaging set for chromophore separation and oxygen saturation estimation. The separation method is validated through Monte Carlo simulation, as well as on a skin phantom. Results show that subsurface oxygen saturation can be reasonably estimated with good implications for the reconstruction of 3D skin lesion volumes using transillumination towards early detection of malignancy.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE-EMBS International Conference on Biomedical and Health Informatics
Subtitle of host publicationGlobal Grand Challenge of Health Informatics, BHI 2012
Pages729-732
Number of pages4
DOIs
StatePublished - Jul 30 2012
EventIEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on Biomedical and Health Engineering - Hong Kong and Shenzhen, China
Duration: Jan 2 2012Jan 7 2012

Publication series

NameProceedings - IEEE-EMBS International Conference on Biomedical and Health Informatics: Global Grand Challenge of Health Informatics, BHI 2012

Other

OtherIEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on Biomedical and Health Engineering
CountryChina
CityHong Kong and Shenzhen
Period1/2/121/7/12

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Health Informatics

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