TY - GEN
T1 - Blood oxygen saturation estimation in transilluminated images of skin lesions
AU - D'Alessandro, Brian
AU - Dhawan, Atam P.
PY - 2012
Y1 - 2012
N2 - Estimating the oxygen saturation of blood surrounding skin lesions is critical for the early detection of skin cancer and malignancy such as melanoma. Through multispectral transillumination of the skin, a set of images can be obtained which helps visualize areas of subsurface absorption due to chromophores such as melanin, hemoglobin, and deoxyhemoglobin. To relate pixel intensity in these images to spatially located absorption coefficient values, we develop a correction factor to Beer's law, estimated through a Monte Carlo simulation of light propagation in skin, which takes into account the specific geometry of our transillumination imaging apparatus. We then use this relation on the multispectral imaging set for chromophore separation and oxygen saturation estimation. The separation method is validated through Monte Carlo simulation, as well as on a skin phantom. Results show that subsurface oxygen saturation can be reasonably estimated with good implications for the reconstruction of 3D skin lesion volumes using transillumination towards early detection of malignancy.
AB - Estimating the oxygen saturation of blood surrounding skin lesions is critical for the early detection of skin cancer and malignancy such as melanoma. Through multispectral transillumination of the skin, a set of images can be obtained which helps visualize areas of subsurface absorption due to chromophores such as melanin, hemoglobin, and deoxyhemoglobin. To relate pixel intensity in these images to spatially located absorption coefficient values, we develop a correction factor to Beer's law, estimated through a Monte Carlo simulation of light propagation in skin, which takes into account the specific geometry of our transillumination imaging apparatus. We then use this relation on the multispectral imaging set for chromophore separation and oxygen saturation estimation. The separation method is validated through Monte Carlo simulation, as well as on a skin phantom. Results show that subsurface oxygen saturation can be reasonably estimated with good implications for the reconstruction of 3D skin lesion volumes using transillumination towards early detection of malignancy.
UR - http://www.scopus.com/inward/record.url?scp=84864200029&partnerID=8YFLogxK
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U2 - 10.1109/BHI.2012.6211686
DO - 10.1109/BHI.2012.6211686
M3 - Conference contribution
AN - SCOPUS:84864200029
SN - 9781457721779
T3 - Proceedings - IEEE-EMBS International Conference on Biomedical and Health Informatics: Global Grand Challenge of Health Informatics, BHI 2012
SP - 729
EP - 732
BT - Proceedings - IEEE-EMBS International Conference on Biomedical and Health Informatics
T2 - IEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on Biomedical and Health Engineering
Y2 - 2 January 2012 through 7 January 2012
ER -