Bursting in 2-compartment neurons: A case study of the Pinsky-Rinzel model

Amitabha Bose, Victoria Booth

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

The two-compartment Pinsky-Rinzel model of a hippocampal CA3 pyramidal neuron consists of electrically coupled soma and dendritic compartments, each with active ionic conductances. This model has been widely used in a variety of contexts, but little analysis has been performedon its bursting solutions. In this chapter, we provide a geometric framework to study the Pinsky-Rinzel model. Using a combination of analysis and simulations, we identify neuronal mechanisms responsible for certain salient features of the model such as burst initiation and somatic-dendritic ping-pong. Some of these mechanisms are then demonstrated in a conceptually simpler, two-compartment Morris-Lecar model.

Original languageEnglish (US)
Title of host publicationBursting
Subtitle of host publicationThe Genesis of Rhythm in the Nervous System
PublisherWorld Scientific Publishing Co.
Pages123-144
Number of pages22
ISBN (Electronic)9789812703231
ISBN (Print)981256506X, 9789812565068
DOIs
StatePublished - Jan 1 2005

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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