Bursting in 2-compartment neurons: A case study of the Pinsky-Rinzel model

Amitabha Bose, Victoria Booth

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


The two-compartment Pinsky-Rinzel model of a hippocampal CA3 pyramidal neuron consists of electrically coupled soma and dendritic compartments, each with active ionic conductances. This model has been widely used in a variety of contexts, but little analysis has been performedon its bursting solutions. In this chapter, we provide a geometric framework to study the Pinsky-Rinzel model. Using a combination of analysis and simulations, we identify neuronal mechanisms responsible for certain salient features of the model such as burst initiation and somatic-dendritic ping-pong. Some of these mechanisms are then demonstrated in a conceptually simpler, two-compartment Morris-Lecar model.

Original languageEnglish (US)
Title of host publicationBursting
Subtitle of host publicationThe Genesis of Rhythm in the Nervous System
PublisherWorld Scientific Publishing Co.
Number of pages22
ISBN (Electronic)9789812703231
ISBN (Print)981256506X, 9789812565068
StatePublished - Jan 1 2005

All Science Journal Classification (ASJC) codes

  • General Medicine


Dive into the research topics of 'Bursting in 2-compartment neurons: A case study of the Pinsky-Rinzel model'. Together they form a unique fingerprint.

Cite this