Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions

Elvan Dogan, Asli Kisim, Gizem Bati-Ayaz, Gregory J. Kubicek, Devrim Pesen-Okvur, Amir K. Miri

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Microfluidic tumors-on-chips models have revolutionized anticancer therapeutic research by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) includes various cell types and cancer stem cells (CSCs), which are postulated to regulate the growth, invasion, and migratory behavior of tumor cells. In this review, the biological niches of the TME and cancer cell behavior focusing on the behavior of CSCs are summarized. Conventional cancer models such as 3D cultures and organoid models are reviewed. Opportunities for the incorporation of CSCs with tumors-on-chips are then discussed for creating tumor invasion models. Such models will represent a paradigm shift in the cancer community by allowing oncologists and clinicians to predict better which cancer patients will benefit from chemotherapy treatments.

Original languageEnglish (US)
Article number2100017
JournalAdvanced NanoBiomed Research
Issue number11
StatePublished - Nov 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Engineering (miscellaneous)
  • Biomaterials


  • cancer stem cells
  • microfluidics
  • tumor microenvironments
  • tumors-on-chips


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