TY - GEN
T1 - Capillary Flow Dynamics of Blood With Varied Hematocrit in Microfluidic Platforms
AU - Nunna, Bharath Babu
AU - Wang, Yudong
AU - Talukder, Niladri
AU - Lee, Eon Soo
N1 - Funding Information:
ACKNOWLEDGMENT The authors acknowledge the support from New Jersey Institute of Technology (NJIT), Weber State University (WSU) and National Science Foundation (NSF). This research is carried out in part at the Center for Functional Nanomaterials, Brookhaven National Laboratory, which is supported by the U.S. Department of Energy, Office of Basic Energy Sciences, under Contract No. DE-SC0012704.
Funding Information:
Niladri Talukder is with Mechanical and Industrial Engineering Department, New Jersey Institute of Technology, Newark, NJ 07102 USA. (email: nt22@njit.edu) *Eon Soo Lee (corresponding author) was with Stanford University, Stanford, CA 94305 USA. He is now with Mechanical and Industrial Engineering Department, New Jersey Institute of Technology, Newark, NJ 07102 USA. (phone: 973-596-3318; e-mail: eonsoo.lee@njit.edu). **Research supported by National Science Foundation Grant
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Blood is a complex fluid with non-newtonian behavior. Though the blood plasma is newtonian in nature, the Red Blood Cells (RBCs) in the blood contribute to the non-newtonian behavior. The study of the influence of the hematocrit (percentage of RBCs in the whole blood) in the capillary flow of the whole blood is highly desired to understand the non-newtonian flow of blood and change on the flow dynamics of whole blood with different concentrations of RBCs. In the capillary flow dynamics, the study of contact angle and its variations play a key role. So, in this manuscript the contact angle of the whole blood drop and the flow velocity of the whole blood with different hematocrit on the polydimethylsiloxane (PDMS) surface is studied with detailed scientific experiments. The contact angle was measured for whole blood drop with hematocrit of 35%, 40%, 45%, and 50% as 34°, 38°, 44°, and 48° respectively. Also, the flow velocity that is directly influenced by the contact angle in the capillary flow is measured with whole blood with hematocrit of 35%, 40%, 45%, and 50% as 9.23 mm/s, 8.45 mm/s, 7.32 mm/s, and 6.67 mm/s respectively. The experimental results helps to conclude that the increased hematocrit in the whole blood is increasing the contact angle and decreasing the flow velocity. Clinical Relevance - The study of the capillary flow dynamics of whole blood with different hematocrit helps the physicians to establish more accurate analysis of blood flow with different concentrations of RBCs.
AB - Blood is a complex fluid with non-newtonian behavior. Though the blood plasma is newtonian in nature, the Red Blood Cells (RBCs) in the blood contribute to the non-newtonian behavior. The study of the influence of the hematocrit (percentage of RBCs in the whole blood) in the capillary flow of the whole blood is highly desired to understand the non-newtonian flow of blood and change on the flow dynamics of whole blood with different concentrations of RBCs. In the capillary flow dynamics, the study of contact angle and its variations play a key role. So, in this manuscript the contact angle of the whole blood drop and the flow velocity of the whole blood with different hematocrit on the polydimethylsiloxane (PDMS) surface is studied with detailed scientific experiments. The contact angle was measured for whole blood drop with hematocrit of 35%, 40%, 45%, and 50% as 34°, 38°, 44°, and 48° respectively. Also, the flow velocity that is directly influenced by the contact angle in the capillary flow is measured with whole blood with hematocrit of 35%, 40%, 45%, and 50% as 9.23 mm/s, 8.45 mm/s, 7.32 mm/s, and 6.67 mm/s respectively. The experimental results helps to conclude that the increased hematocrit in the whole blood is increasing the contact angle and decreasing the flow velocity. Clinical Relevance - The study of the capillary flow dynamics of whole blood with different hematocrit helps the physicians to establish more accurate analysis of blood flow with different concentrations of RBCs.
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U2 - 10.1109/HI-POCT54491.2022.9744073
DO - 10.1109/HI-POCT54491.2022.9744073
M3 - Conference contribution
AN - SCOPUS:85128635184
T3 - Healthcare Innovations and Point of Care Technologies Conference, HI-POCT 2022
SP - 1
EP - 4
BT - Healthcare Innovations and Point of Care Technologies Conference, HI-POCT 2022
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2022 IEEE-EMB Special Topic Conference on Healthcare Innovations and Point of Care Technologies, HI-POCT 2022
Y2 - 10 March 2022 through 11 March 2022
ER -